{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T17:38:28Z","timestamp":1779903508799,"version":"3.53.1"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High\u2010mobility group box 1 (HMGB\u20101) is a highly abundant pro\u2010inflammatory protein associated with the pathogenesis of inflammatory and autoimmune diseases. HMGB\u20101 expression level increases in patients with psoriasis vulgaris (PV). However, HMGB\u20101 expression in patients with generalized pustular psoriasis (GPP) is unknown. In this study, we investigated HMGB\u20101 expression in GPP. HMGB\u20101 expression levels were examined in the skin and serum of patients with GPP, PV, atopic dermatitis (AD) and healthy controls (HC) using enzyme\u2010linked immunosorbent assay and immunohistochemistry. The elevation in HMGB\u20101 expression was significantly higher in GPP patients than in PV, AD and HC patients. In addition, patients with GPP had elevated serum HMGB\u20101 levels compared with those with AD and HC. Furthermore, serum HMGB\u20101 levels were significantly decreased after systemic treatment. In the correlation analysis, a significant positive correlation was detected between serum HMGB\u20101 levels and the Japanese severity score for GPP. HMGB\u20101 may be involved in the pathogenesis of GPP and can be useful to evaluate disease severity and the effectiveness of GPP treatment.<\/jats:p>","DOI":"10.1111\/1346-8138.15467","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T01:35:58Z","timestamp":1593653758000},"page":"1033-1036","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Increased level of high mobility group box 1 in the serum and skin in patients with generalized pustular psoriasis"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6654-6175","authenticated-orcid":false,"given":"Tomoya","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0297-6627","authenticated-orcid":false,"given":"Yukie","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0598-856X","authenticated-orcid":false,"given":"Yuko","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Takamura","sequence":"additional","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Aihara","sequence":"additional","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14949"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14523"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000250839"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1594"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg516"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-3906"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.7.3890"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2013.00164"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13162"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1330-0"},{"key":"e_1_2_6_12_1","unstructured":"KohnoY.[Identification of Causative and Exacerbation Factors of Atopic Dermatitis and Studies for Improvement of Living Environment to Prevent the Development and Ex\u2010acerbation of Symptoms. 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