{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T03:51:42Z","timestamp":1781841102257,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"LEO Pharma KK"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Poor adherence to treatment makes achievement of expected therapeutic outcomes more difficult, especially in chronic disorders like psoriasis. There are several critical factors that affect adherence, including therapeutic efficacy, patient satisfaction, patient treatment preferences and ease of application, especially in topical therapy. The fixed combination of calcipotriol plus betamethasone dipropionate in a gel formulation (Cal\/BDP gel) has been recommended as a first\u2010line topical treatment for mild to moderate plaque. To examine whether Cal\/BDP gel can effectively improve treatment adherence, we investigated the effects of once\u2010daily Cal\/BDP gel on factors affecting adherence at weeks 4, 8 and 12 in patients with plaque psoriasis who had poor adherence. A total of 46 subjects were enrolled and 41 subjects (26 men, 15 women; mean age, 50.5\u00a0years) were included in the analysis. The following items were evaluated: Patient Preference Questionnaire, nine\u2010item Treatment Satisfaction Questionnaire for Medication, Physician\u2019s Global Assessment (PGA), modified Psoriasis Area and Severity Index (m\u2010PASI), body surface area (BSA), pruritus, medication adherence and application time. In patients with poor adherence, many preferred treatment with Cal\/BDP gel and evaluated its convenience as \u201cexcellent\u201d at weeks 4 and 12. At week 12, the proportion of \u201cclear\u201d\/\u201dvery mild\u201d ratings using PGA reached 20.5%, the change from baseline on m\u2010PASI was \u221261.3% and the change from baseline on BSA was \u221239.8%, suggesting that the skin symptoms of psoriasis had improved greatly. In most patients, the longer they used Cal\/BDP gel, the greater their preference and satisfaction and the higher the therapeutic effect, which increased markedly over 12\u00a0weeks. These results suggest that Cal\/BDP gel can effectively improve treatment adherence. Conversely, high adherence to Cal\/BDP gel must enhance the therapeutic effect. Therefore, we expect that Cal\/BDP gel could become the mainstay of topical psoriasis treatment in patients with poor adherence.<\/jats:p>","DOI":"10.1111\/1346-8138.15522","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T05:36:28Z","timestamp":1596173788000},"page":"1249-1256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Patient satisfaction and efficacy of calcipotriol plus betamethasone dipropionate gel in plaque psoriasis patients with poor adherence"],"prefix":"10.1111","volume":"47","author":[{"given":"Hidetoshi","family":"Takahashi","sequence":"first","affiliation":[{"name":"Takagi Dermatology Clinic Obihiro Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyasu","family":"Katayama","sequence":"additional","affiliation":[{"name":"Sagamiono Skin Clinic Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Uwajima","sequence":"additional","affiliation":[{"name":"Uwajima Dermatology Clinic Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Koda","sequence":"additional","affiliation":[{"name":"Aozora Dermatology Clinic Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Oyumino Rainbow Skin Clinic Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsumi","family":"Tanito","sequence":"additional","affiliation":[{"name":"Tsukuda River\u2010City Dermatology Clinic Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Toyosu Park city Skin Clinic Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koma","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Nakano Dermatology Clinic Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8272-4488","authenticated-orcid":false,"given":"Hidemi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Atago Dermatology Clinic Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.08.028"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12443"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050100"},{"key":"e_1_2_7_5_1","volume-title":"Global Report on 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