{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T10:01:52Z","timestamp":1773741712644,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Programmed death 1 (PD\u20101) inhibitors are increasingly used for the treatment of malignancies. Despite the clinical benefits, unpredictable and potentially fatal side\u2010effects may occur. We report a psoriatic patient who developed systemic capillary leak syndrome (SCLS) after starting a PD\u20101 checkpoint inhibitor. In order to determine which factors could trigger the development of SCLS in a patient with stable psoriasis after starting anti\u2010PD\u20101 therapy, serum cytokines were serially measured before and after the development of SCLS in this patient. We also retrospectively reviewed 28 previously reported patients presenting clinical exacerbations of pre\u2010existing psoriasis or the de novo induction of psoriasis after anti\u2010PD\u20101 therapy. In 16 of the 28 patients (57.1%), the interval between last anti\u2010PD\u20101 therapy and exacerbations of pre\u2010existing psoriasis or the de novo induction of psoriasis was less than 28\u00a0days. The timing of the onset of SCLS in this patient was coincident with the increase in lymphocyte counts and at 22\u00a0days after last anti\u2010PD\u20101 therapy. In 75%, however, anti\u2010PD\u20101 therapy was able to be restarted and was tolerated well. Increased levels of interleukin (IL)\u20102, IL\u20106, interferon\u2010\u03b3 and tumor necrosis factor\u2010\u03b1, in addition to a persistent increase in vascular endothelial growth factor (VEGF), were detected at onset of SCLS. An increase in pro\u2010inflammatory cytokines and VEGF, when combined with a rapid and sequential recovery of neutrophils and lymphocytes after anti\u2010PD\u20101 therapy, would predict the development of SCLS. Clinicians need to be aware that patients with psoriasis are at risk of a potentially fatal disease, SCLS, when anti\u2010PD\u20101 therapy is started.<\/jats:p>","DOI":"10.1111\/1346-8138.15541","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T14:37:07Z","timestamp":1597415827000},"page":"1322-1325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Systemic capillary leak syndrome triggered by anti\u2010programmed death 1 checkpoint inhibitor in psoriasis"],"prefix":"10.1111","volume":"47","author":[{"given":"Yoshiyasu","family":"Umeda","sequence":"first","affiliation":[{"name":"Department of Dermatology Kawasaki Medical School Kurashiki Japan"},{"name":"Dermatology Kawasaki Medical School Kawasaki General Medical Center Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kawasaki Medical School Kurashiki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiko","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Dermatology Kawasaki Medical School Kawasaki General Medical Center Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3701-5575","authenticated-orcid":false,"given":"Yumi","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kawasaki Medical School Kurashiki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(60)90018-8"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.6129"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05777.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2017.07.007"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14011"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2989"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.10-RAI-0260"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14074"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.15541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.15541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.15541","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.15541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T06:53:44Z","timestamp":1693724024000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.15541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,13]]},"references-count":8,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/1346-8138.15541"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.15541","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,13]]},"assertion":[{"value":"2020-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}