{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:19:36Z","timestamp":1747181976813,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K21328","20K17353"],"award-info":[{"award-number":["19K21328","20K17353"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Merkel cell carcinoma (MCC) is an aggressive neoplasm and patients with metastasis have poor survival outcomes. Recently, avelumab, an anti\u2010programmed death ligand 1 (PD\u2010L1) immune checkpoint inhibitor, was approved for first\u2010line treatment in patients with metastatic MCC. While the administration interval of avelumab is every 2\u00a0weeks, the durable effect of a single administration of avelumab is unknown. Additionally, the effect of avelumab in pure MCC or combined MCC concurrent with non\u2010MCC histology has not been fully elucidated. Herein, we report a case of combined MCC concurrent with squamous cell carcinoma; the patient had a complete response after a single administration of avelumab. Although the levels of avelumab were outside the detection limit within 12\u00a0weeks, a remarkable efficacy remained for more than 28\u00a0weeks after administration. Immunohistochemical analyses revealed that the expression of PD\u2010L1 and Merkel cell polyomavirus large T antigen was almost negative or only partial in the primary tumor lesion of this patient. Conversely, thyroid transcription factor 1 (TTF\u20101) expression was positive in the primary MCC lesion, which is consistent with a previous report that combined MCC is positive for TTF\u20101 expression. In conclusion, this case study presents a rare case of TTF\u20101\u2010positive combined MCC showing complete response after a single administration of avelumab.<\/jats:p>","DOI":"10.1111\/1346-8138.15543","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T14:54:01Z","timestamp":1597416841000},"page":"1317-1321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single administration of avelumab induced a complete response in thyroid transcription factor 1\u2010positive combined Merkel cell carcinoma"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3725-6213","authenticated-orcid":false,"given":"Hisashi","family":"Kanemaru","sequence":"first","affiliation":[{"name":"Department of Dermatology and Plastic Surgery Faculty of Life Sciences Kumamoto University Kumamoto 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Plastic Surgery Faculty of Life Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0988-2471","authenticated-orcid":false,"given":"Jun","family":"Aoi","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery Faculty of Life Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takamitsu","family":"Makino","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery Faculty of Life Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Graduate School of Medical Sciences Kumamoto University Kumamoto 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