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Although the etiopathophysiology has not yet been fully elucidated, the binding of Fas ligand (FasL, CD95L) to the Fas receptor (CD95) was shown to play a key role in the induction of apoptosis in this syndrome. The knowledge of the role of immunoglobulin G (IgG) in inhibition of Fas\u2010mediated apoptosis contributed to the introduction of i.v. Ig (IVIg) in the therapy of TEN patients. Despite great enthusiasm for this therapy at the end of the 1990s, subsequent studies in various populations and meta\u2010analyses could not unequivocally confirm the efficacy of the IVIg\u2010based treatment concept. Today, therefore, we are faced with the dilemmas of how to adjust therapy of TEN patients most effectively, which patients could benefit from IVIg therapy and what dose of the preparation should be administrated. The ground\u2010breaking question is: do the host genetic profiles influence the responsiveness and side\u2010effects of IVIg therapy in TEN patients? Based on recent pharmacological, immunological and genetic findings, we suggest that the variability of IVIg therapy outcomes in TEN patients may be related to functional variants in <jats:italic>Fas<\/jats:italic>, <jats:italic>FasL<\/jats:italic> and Fc\u2010\u03b3 receptor genes. This novel concept could lead to improved quality of care for patients with TEN, facilitating personalized therapy to reduce mortality.<\/jats:p>","DOI":"10.1111\/1346-8138.15583","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T07:31:18Z","timestamp":1600327878000},"page":"1236-1248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Responsiveness to i.v. immunoglobulin therapy in patients with toxic epidermal necrolysis: A novel pharmaco\u2010immunogenetic concept"],"prefix":"10.1111","volume":"47","author":[{"given":"Petra","family":"Borilova Linhartova","sequence":"first","affiliation":[{"name":"Institute of Medical Genetics, Faculty of Medicine Masaryk University Brno Czech Republic"},{"name":"Department of Pathophysiology, Faculty of Medicine Masaryk University Brno Czech Republic"},{"name":"Clinic of Stomatology, Faculty of Medicine Masaryk University Brno Czech Republic"},{"name":"Department of Molecular Pharmacy, Faculty of Pharmacy Masaryk University Brno Czech Republic"},{"name":"Clinic of Maxillofacial Surgery, Institution shared with University Hospital Brno Faculty of Medicine, Masaryk University Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Gachova","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Faculty of Medicine Masaryk University Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9187-7606","authenticated-orcid":false,"given":"Bretislav","family":"Lipovy","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Institution shared with University Hospital Brno Faculty of Medicine, Masaryk University Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30378-6"},{"issue":"2","key":"e_1_2_9_3_1","first-page":"203","article-title":"Severe cutaneous adverse reactions to drugs (SCAR): definitions, diagnostic criteria, genetic predisposition","volume":"27","author":"Roujeau JC","year":"2009","journal-title":"Dermatologica Sin"},{"issue":"11","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1365-2133.1956.tb12766.x","article-title":"Toxic epidermal necrolysis: an eruption resembling scalding of the skin","volume":"68","author":"Leyll A","year":"1956","journal-title":"Br J Dermatol"},{"issue":"6","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1001\/archderm.1991.01680050083008","article-title":"Toxic epidermal necrolysis and Stevens\u2010Johnson syndrome. 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