{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:25:40Z","timestamp":1762431940894,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neonatal lupus erythematosus (LE) is a rare immune\u2010mediated disease caused by placental transport of maternal anti\u2010SSA\/Ro, anti\u2010SSB\/La and\/or anti\u2010U1RNP antibodies. Here, we demonstrate two cases of neonatal LE, in both of which cutaneous LE was exacerbated by inoculation. To our knowledge, cases worsening neonatal LE after administration of vaccines have not been reported. In case 1, not only exacerbation of pre\u2010existing annular erythema but also spreading of new erythematous lesions to the trunk and extremities were induced following vaccination. Of interest, all of the lesions simultaneously improved. By contrast, in case 2, pre\u2010existing facial erythema became prominent without spreading to other sites. The mother of case 1 had Sj\u00f6gren\u2019s syndrome, whereas in case 2, the mother was diagnosed with Sj\u00f6gren\u2019s syndrome on this occasion for the first time. Immunohistochemistry in case 1 revealed interleukin (IL)\u201017\u2010positive cells infiltrating into the papillary dermis, and CD123\u2010positive plasmacytoid dendritic cells in the papillary dermis and the deep reticular dermis. Both innate immune response and IL\u201017 mediated inflammation following vaccination are speculated as a possible mechanism of the deterioration of LE lesions in our juvenile cases. Caution is necessary since neonatal LE can be worsened following vaccination.<\/jats:p>","DOI":"10.1111\/1346-8138.15588","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T15:16:17Z","timestamp":1599146177000},"page":"1450-1453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Neonatal lupus erythematosus exacerbated by vaccination"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3652-196X","authenticated-orcid":false,"given":"Masato","family":"Ishikawa","sequence":"first","affiliation":[{"name":"Department of Dermatology Fukushima Medical University Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8771-4206","authenticated-orcid":false,"given":"Tatsuhiko","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fukushima Medical University Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8390-2573","authenticated-orcid":false,"given":"Toshiyuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fukushima Medical University Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-008-0896-4"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.7241\/ourd.20191.30"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2014.12.009"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.03.005"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/79747"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901706"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2011.03.001"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-009-0191-2"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.08.013"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.7.5120"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071450"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2010.03.004"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12723"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030730"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14452"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.15588","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.15588","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.15588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T14:02:30Z","timestamp":1692367350000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.15588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,3]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/1346-8138.15588"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.15588","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"type":"print","value":"0385-2407"},{"type":"electronic","value":"1346-8138"}],"subject":[],"published":{"date-parts":[[2020,9,3]]},"assertion":[{"value":"2020-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}