{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:04:38Z","timestamp":1790928278609,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A scabies burrow is created by a mature female mite laying eggs through the stratum corneum, representing a kind of scabies eruption. We have noticed that the edges of the scabies burrow sometime appear as blackish\u2010gray lines. We named these lines the \u201cgray\u2010edged line\u201d sign, as a new feature of scabies burrows. The gray\u2010edged line sign has the following two tendencies: (i) it is rarely seen on the palm or sole; and (ii) when the burrow follows a curved course, the gray\u2010edged line often forms on the outer wall. Explaining the formation of this sign from clinical findings was difficult, so the aim of the present study was to elucidate the mechanisms underlying the gray\u2010edged line sign. This retrospective study involved collection of data from electronic medical records of patients treated for scabies in our department between April 2015 and February 2020. We treated 32 scabies patients, including 4 patients with the gray\u2010edged line sign. We analyzed clinical features, dermoscopy, histopathology and special stains. Fontana\u2010Masson staining showed melanin staining in three parts: feces; some keratinocytes around the scabies burrows; and the mouth and legs of the scabies mite. The gray\u2010edged line sign appears to represent mite feces containing melanin.<\/jats:p>","DOI":"10.1111\/1346-8138.15650","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T13:30:54Z","timestamp":1602855054000},"page":"190-198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Gray\u2010edged line sign of scabies burrow"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7273-2871","authenticated-orcid":false,"given":"Takashi","family":"Ueda","sequence":"first","affiliation":[{"name":"Department of Dermatology National Hospital Organization Yokohama Medical Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Katsura","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Hospital Organization Yokohama Medical Center Yokohama 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