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Although the exact mechanisms behind its pathogenesis remain unclear, it is evident that the complex interplay among barrier dysfunction, inflammation and itch are critical in its development, progression and chronicity. Abnormalities in filaggrin, intercellular lipids and tight junctions induce barrier\u2010disrupted skin, which produces thymic stromal lymphopoietin, interleukin (IL)\u201025 and IL\u201033; these in turn promote skin inflammation characterized by type 2 immune deviation. This inflammation then downregulates the expression of filaggrin in keratinocytes and exacerbates epidermal barrier dysfunction. Furthermore, various itch mediators\/pruritogens produced during this inflammatory process can act directly on sensory nerves and cause itch. In this review, we summarize the basics and recent advances in our understanding of the pathophysiology of atopic dermatitis focusing on three aspects: barrier dysfunction, skin inflammation and itch.<\/jats:p>","DOI":"10.1111\/1346-8138.15664","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T11:28:45Z","timestamp":1603970925000},"page":"130-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["Basics and recent advances in the pathophysiology of atopic dermatitis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2811-8273","authenticated-orcid":false,"given":"Takeshi","family":"Nakahara","sequence":"first","affiliation":[{"name":"Department of Dermatology Graduate School of Medical Sciences Kyushu University Fukuoka Japan"},{"name":"Division of Skin Surface Sensing Graduate School of Medical Sciences Kyushu University Fukuoka 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