{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:19:51Z","timestamp":1747181991124,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During biologic treatments, attention should be paid to adverse reactions, particularly infectious diseases. Furthermore, drug\u2010induced interstitial lung disease is also known to be associated with biologic therapies. We retrospectively reviewed serum Krebs von den Lungen\u20106 (KL\u20106) levels in psoriatic patients who underwent treatment with seven different biologics. A total of 67 patients who received 80 biologic treatments were evaluated. The 31 anti\u2010tumor necrosis factor (TNF)\u2010\u03b1 treatments consisted of 17 infliximab (IFX) and 14 adalimumab. The 23 anti\u2010interleukin (IL)\u201023 treatments consisted of 14 ustekinumab and nine guselkumab. The 26 anti\u2010IL\u201017 treatments consisted of nine secukinumab, six ixekizumab and 11 brodalumab. The IFX showed significantly increased mean serum KL\u20106 (170.9%), but none of the other treatments showed significant increases. Thirteen of the 17 (75.6%) patients in the IFX and 17 of the 31 (54.8%) patients in the total anti\u2010TNF\u2010\u03b1 group demonstrated at least a 25% increase in serum KL\u20106. Levels exceeding the cut\u2010off (500\u00a0U\/mL) were detected in three patients before treatment and in seven patients after treatment. This study showed that anti\u2010IL\u201017 and anti\u2010IL\u201023 treatments have no significant impact on serum KL\u20106 level. In addition to the influence of IFX, a significantly large number of patients in the IFX group had a history of methotrexate administration associated with psoriatic arthritis, which might have influenced the KL\u20106 level. None of the patients with elevated serum KL\u20106 showed pulmonary changes by computed tomography and\/or X ray.<\/jats:p>","DOI":"10.1111\/1346-8138.15665","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T18:38:08Z","timestamp":1604515088000},"page":"376-379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serum Krebs von den Lungen\u20106 levels in psoriatic patients under treatment with biologics"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8781-2735","authenticated-orcid":false,"given":"Hiroaki","family":"Iwata","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo 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