{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:46:10Z","timestamp":1780375570368,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20ek0109435"],"award-info":[{"award-number":["JP20ek0109435"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acquired idiopathic generalized anhidrosis is a rare disease with unknown etiology. Sudden loss of sweating function adversely affects young patients\u2019 quality of life. Although systemic corticosteroid therapy is the most frequently reported treatment for the disease, its effectiveness is controversial because of the risk of recurrence. To assist clinical decision\u2010making regarding whether to use steroids, we investigated the treatment responsiveness and recurrence rates in patients undergoing steroid pulse therapy and explored factors affecting these rates. We retrospectively collected data of 124 patients who received steroid pulse therapy to calculate the rate of responsiveness to the therapy. We also conducted a time\u2010to\u2010event analysis in a cohort of 57 patients who responded to steroid pulse therapy to estimate the recurrence rate after the therapy. As a result, the response and recurrence rates were 73% and 48%, respectively. Recurrence occurred within 1\u00a0year in most patients. The overall effectiveness of steroid pulse therapy was estimated to be 57% considering the recurrence rate. A delay from onset to treatment and younger age appeared to be negative factors for effectiveness. Moreover, we found a significant seasonal effect on both treatment and recurrence: autumn was the worst season for acquired idiopathic generalized anhidrosis in Japan. Our study revealed that steroid pulse therapy can be expected to be effective in half of treated patients. We recommend starting the therapy promptly after the diagnosis; however, it is also worth considering the season for treatment planning.<\/jats:p>","DOI":"10.1111\/1346-8138.15666","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T13:42:01Z","timestamp":1604497321000},"page":"271-278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prognosis after steroid pulse therapy and seasonal effect in acquired idiopathic generalized anhidrosis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5869-2017","authenticated-orcid":false,"given":"Tadatsune","family":"Iida","sequence":"first","affiliation":[{"name":"Department of Dermatology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minako","family":"Inazawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takichi","family":"Munetsugu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Dermatology Aichi Medical University School of Medicine Nagakute Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Nakazato","sequence":"additional","affiliation":[{"name":"Department of Neurology Saitama Medical University Moroyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1092-1159","authenticated-orcid":false,"given":"Takeshi","family":"Namiki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5773-9485","authenticated-orcid":false,"given":"Hiroo","family":"Yokozeki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,4]]},"reference":[{"key":"e_1_2_6_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13649"},{"key":"e_1_2_6_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13785"},{"key":"e_1_2_6_3_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314488"},{"key":"e_1_2_6_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.041"},{"key":"e_1_2_6_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(95)00125-L"},{"key":"e_1_2_6_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09113.x"},{"key":"e_1_2_6_3_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.244"},{"key":"e_1_2_6_3_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000142036.54112.57"},{"key":"e_1_2_6_3_10_1","first-page":"940","article-title":"Prognosis of acquired idiopathic generalized anhidrosis","volume":"15","author":"Cao R","year":"2017","journal-title":"J Ger Soc Dermatol"},{"key":"e_1_2_6_3_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2006.00064.x"},{"key":"e_1_2_6_3_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440314"},{"key":"e_1_2_6_3_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05872.x"},{"key":"e_1_2_6_3_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11112.x"},{"key":"e_1_2_6_3_15_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.1050"},{"key":"e_1_2_6_3_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13285"},{"key":"e_1_2_6_3_17_1","unstructured":"Japan Meteorological Agency[homepage on the internet].2020. Available from URL:https:\/\/www.jma.go.jp\/jma\/indexe.html"},{"key":"e_1_2_6_3_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_6_3_19_1","unstructured":"R Core Team.R: A language and environment for statistical computing.2018. Available from URL:https:\/\/www.r\u2010project.org\/"},{"key":"e_1_2_6_3_20_1","unstructured":"Herv\u00e9M.RVAideMemoire: testing and plotting procedures for biostatistics. R Package.2020.http:\/\/cran.r\u2010project.org\/package=RVAideMemoire"},{"key":"e_1_2_6_3_21_1","unstructured":"Cancer Therapy Evaluation Program National Cancer Institute: Common Terminology Criteria for Adverse Events (CTCAE) v5.0.2017. Available from URL:https:\/\/ctep.cancer.gov\/protocolDevelopment\/electronic_applications\/ctc.htm"},{"key":"e_1_2_6_3_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13182"},{"key":"e_1_2_6_3_23_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1820"},{"key":"e_1_2_6_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2017.09.011"},{"key":"e_1_2_6_3_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00484-020-01898-w"},{"key":"e_1_2_6_3_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00484-010-0325-1"},{"key":"e_1_2_6_3_27_1","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.45.921"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.15666","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.15666","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.15666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T17:55:48Z","timestamp":1693677348000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.15666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,4]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/1346-8138.15666"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.15666","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.738983006.793581294","asserted-by":"object"}]},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,4]]},"assertion":[{"value":"2020-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}