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The features of this process are shortening of the anagen phase in hair cycling and progressive miniaturization of the hair follicle. However, the mechanisms in androgenetic alopecia are still unclear, and the treatment methods are also limited. Therefore, further study on the pathogenesis and new therapies for androgenetic alopecia are urgently needed. In this study, we found that endogenous autophagy was severely impaired, accompanied by increased apoptosis in early catagen\u2010like miniaturized hair follicles from the balding scalps of androgenetic alopecia patients. Moreover, inhibition of autophagy using 3\u2010methyladenine could induce apoptosis, premature hair follicle regression and slow down the hair growth in organ\u2010cultured hair follicles. Taken together, these results suggest that impairment of autophagy could be a potential mechanism in androgenetic alopecia.<\/jats:p>","DOI":"10.1111\/1346-8138.15672","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T12:36:14Z","timestamp":1606826174000},"page":"289-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Impairment of autophagy may be associated with follicular miniaturization in androgenetic alopecia by inducing premature catagen"],"prefix":"10.1111","volume":"48","author":[{"given":"Weiwen","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery Nanfang Hospital of Southern Medical University Guangzhou China"},{"name":"Laboratory for Tissue Microenvironment RIKEN Center for Biosystems Dynamics Research (BDR) Kobe 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