{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:05:32Z","timestamp":1773277532232,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:00:00Z","timestamp":1612396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Generalized pustular psoriasis (GPP) represents the rarest form of psoriasis, which may be potentially fatal. In the last decade, (likely) pathogenic variants in the <jats:italic>IL36RN<\/jats:italic>, <jats:italic>CARD14<\/jats:italic> and <jats:italic>AP1S3<\/jats:italic> genes have been associated with monogenic GPP forms. Despite these advances, the genetic basis of most patients with GPP remains unidentified. Treatment of GPP patients is often difficult, with no consensus about the best available options to date. We report herein an infant with severe GPP in whom the disease started at the age of 2\u00a0months. Genetic investigations identified a heterozygous pathogenic variant in the <jats:italic>IL36RN<\/jats:italic> gene associated with a heterozygous variant of uncertain significance in the <jats:italic>CARD14<\/jats:italic> gene. After previous treatment failures with acitretin, cyclosporin and anakinra, treatment with the interleukin\u201017 antagonist secukinumab resulted in a dramatic and prompt positive response that persisted at 12\u2010month follow up. According to our experience, we believe secukinumab can be an effective and safe treatment for pediatric patients with GPP even before 1\u00a0year of age.<\/jats:p>","DOI":"10.1111\/1346-8138.15673","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T03:24:11Z","timestamp":1612754651000},"page":"907-910","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Excellent response to secukinumab in an infant with severe generalized pustular psoriasis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1866-6989","authenticated-orcid":false,"given":"Cristina","family":"L\u00f3pez\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Dermatology Department Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina 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