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This study aimed to investigate the immunohistochemical changes in the human skin after SR\u2010T100 treatment. An immunohistochemical study was performed and the changes in photocarcinogenesis and photoaging markers after 16\u2010week SR\u2010T100 gel treatment were documented. SR\u2010T100 gel treatment for 16\u00a0weeks resulted in complete remission in nine AK lesions and partial remission in four AK lesions. SR\u2010T100 gel abolished the expression of mutant p53 and SOX2 and restored the expression of NOTCH1. Additionally, SR\u2010T100 gel improved wrinkling in human skin, while restoring the expression of lamin B1 and increasing synthesis of new elastic fibers. SR\u2010T100 gel had therapeutic effects on photocarcinogenesis and photoaging of photodamaged skin with AK.<\/jats:p>","DOI":"10.1111\/1346-8138.15703","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T04:15:49Z","timestamp":1610943349000},"page":"344-352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of <i>Solanum undatum<\/i> extract (SR\u2010T100) on photocarcinogenesis and photoaging of actinic keratosis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3897-6522","authenticated-orcid":false,"given":"Chao\u2010Chun","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"International Center for Wound Repair and Regeneration National Cheng Kung University Tainan 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