{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T05:54:20Z","timestamp":1769061260499,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Trimethoprim\u2013sulfamethoxazole (TMP\/SMX) combination is used for the prophylaxis of <jats:italic>Pneumocystis<\/jats:italic> pneumonia (PCP). Although TMP\/SMX is frequently used in dermatology for cases treated with corticosteroids and\/or immunosuppressants, it is often difficult to continue the administration of TMP\/SMX due to adverse events. There are only a few reported studies on the prophylaxis of PCP in dermatology. This is the first review focused on adverse events of TMP\/SMX among patients with dermatological diseases compared with previous reports. In this study, we retrospectively investigated 132 cases treated with TMP\/SMX and examined the adverse events. Adverse events occurred in 32 cases (24.2%) and the incidence in this study was higher than in previous reports. Thrombocytopenia occurred in 17 cases (12.5%), which was the most frequent adverse event. The possible causes of adverse events were that the standard dose of TMP\/SMX may be excessive for most Japanese, in addition to the long administration period, and the concomitant use of corticosteroids and\/or immunosuppressants in almost all cases. We must consider the risks of PCP and adverse events of TMP\/SMX in each case. It is desirable to examine possible administration methods that can be continued by adjusting the dose and interval of TMP\/SMX.<\/jats:p>","DOI":"10.1111\/1346-8138.15724","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T21:29:04Z","timestamp":1611610144000},"page":"542-546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Adverse effects of trimethoprim\u2013sulfamethoxazole for the prophylaxis of <i>Pneumocystis<\/i> pneumonia in dermatology"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4023-367X","authenticated-orcid":false,"given":"Hiraku","family":"Kokubu","sequence":"first","affiliation":[{"name":"Department of Dermatology Shiga University of Medical Science Otsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6344-4440","authenticated-orcid":false,"given":"Takeshi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shiga University of Medical Science Otsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shiga University of Medical Science Otsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shiga University of Medical Science Otsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4051-0649","authenticated-orcid":false,"given":"Noriki","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shiga University of Medical Science Otsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13231"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212243272603"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-3944-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/323353"},{"key":"e_1_2_6_6_1","first-page":"85","article-title":"Conventional\u2010dose versus half\u2010dose sulfamethoxazole\u2010trimethoprim for the prophylaxis of pneumocystis pneumonia in patients with systemic rheumatic disease: a non\u2010blind. Randomized Controlled Trial","volume":"73","author":"Abe Y","year":"2019","journal-title":"Acta Med Okayama"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.11.588"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211796"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/520432"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/520433"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-10-199505150-00004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.111152"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2018.11.014"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu094"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.2808"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.15724","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.15724","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.15724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T16:11:50Z","timestamp":1693584710000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.15724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,25]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/1346-8138.15724"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.15724","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,25]]},"assertion":[{"value":"2020-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}