{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T04:12:31Z","timestamp":1781669551385,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Toxic shock syndrome (TSS) is caused by toxic shock syndrome toxin 1 or enterotoxins secreted by <jats:italic>Staphylococcus aureus<\/jats:italic>. Lipopolysaccharide (LPS) has also been shown to play a major role in the development of sepsis. Staphylococcal superantigens and LPS operate synergistically in conditioning cytokine release and lethal shock in mice. An 80\u2010year\u2010old woman was admitted because of a 20% mixed\u2010depth flame burn. Despite two excisions and grafts, necrotic ulcers with methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) colonization remained. On the 7th day after the operation, she developed shock with an erythematous rash. Blood examination revealed evidence of disseminated intravascular coagulation, and liver and renal dysfunction. A blood culture revealed a staphylococcal enterotoxin B (SEB)\u2010producing strain of MRSA and <jats:italic>Klebsiella pneumoniae<\/jats:italic>. The septic symptoms were prolonged, but the condition gradually improved with extensive treatment. T\u2010cell receptor analysis demonstrated a marked accumulation of SEB\u2010mediated V\u03b2 T cells. Stimulation of peripheral blood mononuclear cells in the recovery phase with SEB and LPS induced additive effects on tumor necrosis factor\u2010\u03b1, interferon\u2010\u03b3, and interleukin\u20106 production. Although the present case did not fulfill the clinical criteria for TSS, the additive effects of SEB and LPS might have caused the severe septic shock.<\/jats:p>","DOI":"10.1111\/1346-8138.15729","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T14:11:44Z","timestamp":1610287904000},"page":"547-550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Staphylococcal enterotoxin B\u2010 and lipopolysaccharide\u2010induced toxic shock syndrome in a burn patient"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1595-933X","authenticated-orcid":false,"given":"Osamu","family":"Yamasaki","sequence":"first","affiliation":[{"name":"Department of Dermatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama 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