{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:05:19Z","timestamp":1789430719322,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>As a novel method of ivermectin (IVM) administration for the treatment of scabies, we devised a whole\u2010body bathing (WBB), in which patients are immersed in a fluid that contains IVM. A multi\u2010institutional trial for elderly patients with scabies was conducted to investigate the efficacy and safety of IVM\u2010WBB. Seven elderly patients with scabies were enrolled and received IVM\u2010WBB up to four times at 1\u2010week interval. The cure for scabies was defined as the absence of mites in two consecutive microscopic or dermoscopic examinations at weekly intervals and the absence of new skin lesions indicative of scabies. Consequently, the cure rate on day 22, the primary end\u2010point, was 71.4%, and all patients had been cured until day 29. Additionally, neither significant adverse events nor clinically problematic abnormal blood test values were obtained. Furthermore, no IVM was detected in the optional plasma (five cases) collected for IVM measurement after bathing. These results suggest that IVM\u2010WBB was effective to treat scabies, causing no serious adverse events and with a very low internal exposure of IVM.<\/jats:p>","DOI":"10.1111\/1346-8138.15746","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T06:21:45Z","timestamp":1610259705000},"page":"559-563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Case series of elderly patients with scabies topically applied with ivermectin via whole\u2010body bathing"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9604-3667","authenticated-orcid":false,"given":"Masayo","family":"Komoda","sequence":"first","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Japan"},{"name":"Center of Translational Research Research Institute for Science and Technology Tokyo University of Science Noda Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Miyajima","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics Meiji Pharmaceutical University Tokyo Japan"},{"name":"Department of Biopharmaceutics Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Machi","family":"Koshino","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunta","family":"Akutsu","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Ozeki","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniko","family":"Makigami","sequence":"additional","affiliation":[{"name":"Tsubasa Home Care Clinic Ohta Japan"},{"name":"Department of Rehabilitation Ota Hospital Higashikagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.006"},{"key":"e_1_2_7_3_1","volume-title":"World Health Organization Model List of Essential Medicines","author":"WHO.net. WHO online publications"},{"key":"e_1_2_7_4_1","first-page":"1","article-title":"Ivermectin and permethrin for treating scabies (Review)","volume":"4","author":"Rosumeck S","year":"2018","journal-title":"Cochrane Database of Sys Rev"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13896"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13321"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12728"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13628"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.12.1618"},{"key":"e_1_2_7_10_1","first-page":"HC01","article-title":"Comparative study of efficacy of oral ivermectin versus some topical anti\u2010scabies drugs in the treatment of scabies","volume":"8","author":"Manjhi PK","year":"2014","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006549"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-020-04608-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-0983-z"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.15746","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.15746","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.15746","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T16:12:01Z","timestamp":1693584721000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.15746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,6]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/1346-8138.15746"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.15746","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,6]]},"assertion":[{"value":"2020-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}