{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T05:01:34Z","timestamp":1751086894465,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,31]],"date-time":"2021-01-31T00:00:00Z","timestamp":1612051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diffuse cutaneous mastocytosis (DCM) is the least common subtype of cutaneous mastocytotis and is generally more severe than other subtypes. We herein report a case of DCM with the consequence of a long\u2010term follow\u2010up. A 4\u2010month\u2010old boy visited with a 3\u2010month history of diffuse erythema that gradually worsened. Darier's sign was positive. The plasma histamine level was 4.95\u00a0ng\/mL, and the serum tryptase and c\u2010Kit (CD117) levels were 33.3 and 27.4\u00a0ng\/mL, respectively. Histopathology of the biopsied specimen showed dermal papillary edema and infiltration of mast cells identified by c\u2010Kit and toluidine blue staining. Amplification and direct sequencing of genomic DNA extracted from the skin biopsy specimen revealed the presence of a deletion of codon 419 in exon 8 (c.1255_1257delGAC [p. Asp419del]). There was no evidence of systemic infiltration of mast cells in this case, and we started topical corticosteroid and oral antihistamine with the diagnosis of DCM. Diffuse erythema subsided constantly with age in parallel with chronological decline of serum tryptase level, and it is no longer apparent presently at the age of 7\u00a0years, leaving only faint brown spots. Blister formation did not occur throughout the course. Our case indicates that spontaneous resolution can be expected even in DCM after a long period of time, and that serum tryptase level serves as a good surrogate marker to monitor the clinical course.<\/jats:p>","DOI":"10.1111\/1346-8138.15764","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T07:21:54Z","timestamp":1612164114000},"page":"672-675","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Diffuse cutaneous mastocytosis: Identification of <i>KIT<\/i> mutation and long\u2010term follow\u2010up with serum tryptase level"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7607-698X","authenticated-orcid":false,"given":"Yuka","family":"Shibata","sequence":"first","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Hirota","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Hyogo College of Medicine Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuo","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Pathology National Hospital Organization Sagamihara National Hospital Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6127-3182","authenticated-orcid":false,"given":"Akihiko","family":"Asahina","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,31]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_5_2_1","DOI":"10.1046\/j.1365-2141.2003.04575.x"},{"doi-asserted-by":"publisher","key":"e_1_2_5_3_1","DOI":"10.1046\/j.1365-2133.2001.04123.x"},{"doi-asserted-by":"publisher","key":"e_1_2_5_4_1","DOI":"10.1111\/1523-1747.ep12468942"},{"doi-asserted-by":"publisher","key":"e_1_2_5_5_1","DOI":"10.1111\/j.1468-3083.2004.00830.x"},{"doi-asserted-by":"publisher","key":"e_1_2_5_6_1","DOI":"10.1158\/0008-5472.CAN-16-2234"},{"doi-asserted-by":"publisher","key":"e_1_2_5_7_1","DOI":"10.1111\/bjd.13567"},{"doi-asserted-by":"publisher","key":"e_1_2_5_8_1","DOI":"10.1002\/ajh.25371"},{"doi-asserted-by":"publisher","key":"e_1_2_5_9_1","DOI":"10.1586\/17474086.2014.955008"},{"doi-asserted-by":"publisher","key":"e_1_2_5_10_1","DOI":"10.2165\/11588890-000000000-00000"},{"doi-asserted-by":"publisher","key":"e_1_2_5_11_1","DOI":"10.1038\/jid.2009.281"},{"doi-asserted-by":"publisher","key":"e_1_2_5_12_1","DOI":"10.1111\/pde.13651"},{"doi-asserted-by":"publisher","key":"e_1_2_5_13_1","DOI":"10.1016\/j.jaip.2018.11.046"},{"doi-asserted-by":"publisher","key":"e_1_2_5_14_1","DOI":"10.1111\/j.1398-9995.2012.02812.x"},{"doi-asserted-by":"publisher","key":"e_1_2_5_15_1","DOI":"10.1182\/blood-2016-09-731893"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.15764","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.15764","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.15764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T13:46:36Z","timestamp":1693575996000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.15764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,31]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/1346-8138.15764"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.15764","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"type":"print","value":"0385-2407"},{"type":"electronic","value":"1346-8138"}],"subject":[],"published":{"date-parts":[[2021,1,31]]},"assertion":[{"value":"2020-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}