{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T22:11:13Z","timestamp":1759702273588,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Muir\u2010Torre syndrome is a hereditary condition characterized by occurrence of sebaceous neoplasms or keratoacanthomas and visceral tumors. The most common mechanism for this syndrome is a constitutional defect in the mismatch repair genes. We report the case of a 67\u2010year\u2010old woman with a mutator L homologue 1 (MLH1) mutation. She had a history of endometrial and colorectal cancers. The patient presented with a typical keratoacanthoma on the right cheek and numerous sebaceous neoplasms on the face and trunk. Seven sebaceous adenomas and a low\u2010grade sebaceous carcinoma were excised. Most sebaceous adenomas showed dermoscopic features such as some yellow comedo\u2010like globules and curved vessels in creamy\u2010white areas. Moreover, they revealed pathological features such as keratoacanthoma\u2010like architecture and peritumoral or intratumoral lymphocytes. One of these sebaceous adenomas indicated histopathologically spontaneous regression and another was continuous with the hair follicle. Immunohistochemical staining for mismatch repair proteins revealed loss of expression for MLH1 and postmeiotic segregation increased 2 (PMS2) proteins in tumor cells nuclei in both keratoacanthoma and sebaceous adenoma. Nuclei in overhanging epithelial lips of the keratoacanthoma were also negative. These findings suggest that the type of Muir\u2010Torre syndrome\u2010related cutaneous tumor may have been affected by mismatch repair protein deficient sites in the pilosebaceous unit.<\/jats:p>","DOI":"10.1111\/1346-8138.15772","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T20:41:48Z","timestamp":1612298508000},"page":"690-694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A case of Muir\u2010Torre syndrome with a keratoacanthoma and sebaceous neoplasms: Clinicopathological features and a speculation on the pathogenesis of cutaneous tumor type"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3114-1693","authenticated-orcid":false,"given":"Eriko","family":"Takayama","sequence":"first","affiliation":[{"name":"Department of Dermatology Konan Medical Center Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Konan Medical Center Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6969-1653","authenticated-orcid":false,"given":"Toshihiro","family":"Takai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hyogo Cancer Center Akashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4165-1809","authenticated-orcid":false,"given":"Keisuke","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hyogo Cancer Center Akashi Japan"},{"name":"Department of Pathology Itabashi Central Clinical Laboratory Tokyo Japan"},{"name":"Department of Pathology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan"},{"name":"Department of Diagnostic Pathology Shizuoka Cancer Center Hospital Nagaizumi Japan"},{"name":"Department of Diagnostic Pathology and Cytology Osaka International Cancer Institute Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1016\/j.jaad.2015.09.074"},{"key":"e_1_2_6_3_1","first-page":"13030\/qt8sg5w98","article-title":"Lynch Syndrome and Muir\u2010Torre Syndrome: An update and review on the genetics, epidemiology, and management of two related disorders","volume":"23","author":"Le S","year":"2017","journal-title":"Dermatol Online 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