{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:51:19Z","timestamp":1790862679444,"version":"4.1.0"},"reference-count":8,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fatty acid binding protein (FABP) is a family of transport proteins for fatty acid (FA). Epidermal FABP (E\u2010FABP) is highly expressed by resident memory T cells (T<jats:sub>RM<\/jats:sub>) in the skin. It supports the uptake of exogenous FA for long\u2010term survival of skin T<jats:sub>RM<\/jats:sub>. Mycosis fungoides (MF) is regarded as malignancy of skin T<jats:sub>RM<\/jats:sub>. In this study, we investigated E\u2010FABP expression in psoriasis vulgaris (PV), atopic dermatitis (AD), MF, and S\u00e9zary syndrome (SS). E\u2010FABP mRNA levels in PV were much higher than those in healthy controls. E\u2010FABP mRNA levels in AD and MF\/SS lesional skin were also significantly higher than those of normal skin. By immunohistochemical staining, E\u2010FABP was positive in MF\/SS lesional skin. Interestingly, E\u2010FABP was stained positive in epidermotropic lymphoid cells in patch, plaque, and erythrodermic lesions of MF\/SS, suggesting that a part of tumor cells expressed E\u2010FABP. In tumorous lesions, however, most dermal tumor cells were negative for E\u2010FABP. Immunohistochemical staining using patch\/plaque lesions and tumorous lesions from the same patients also revealed that E\u2010FABP expression decreased in tumorous lesions. Our study has suggested that MF\/SS tumor cells express E\u2010FABP, whose expression decreases with loss of epidermotropism.<\/jats:p>","DOI":"10.1111\/1346-8138.15775","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T22:45:00Z","timestamp":1612997100000},"page":"685-689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mycosis fungoides and S\u00e9zary syndrome tumor cells express epidermal fatty acid\u2010binding protein, whose expression decreases with loss of epidermotropism"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0429-9033","authenticated-orcid":false,"given":"Naomi","family":"Takahashi\u2010Shishido","sequence":"first","affiliation":[{"name":"Department of Dermatology International University of Health and Welfare Chiba Japan"},{"name":"Department of Dermatology The University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1618-329X","authenticated-orcid":false,"given":"Makoto","family":"Sugaya","sequence":"additional","affiliation":[{"name":"Department of Dermatology International University of Health and Welfare Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soshi","family":"Morimura","sequence":"additional","affiliation":[{"name":"Department of Dermatology International University of Health and Welfare Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4212-8278","authenticated-orcid":false,"given":"Hiraku","family":"Suga","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kamijo","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1879-3128","authenticated-orcid":false,"given":"Tomomitsu","family":"Miyagaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Tokyo Graduate School of Medicine Tokyo Japan"},{"name":"Department of Dermatology St. Marianna University School of Medicine Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncoscience.54"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.342"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21379"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60420-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3020363"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000210385"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2010.07.014"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.18228"}],"container-title":["The Journal of 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