{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T15:13:50Z","timestamp":1770995630225,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Metabolic syndrome (MetS) is characterized by insulin resistance, high blood pressure\/sugar, dyslipidemia, and obesity. Whether MetS and its components affect the development of Beh\u00e7et's disease (BD) remains unclear. This study was performed to investigate the associations between metabolic syndrome and risk of BD using nationwide population data. We conducted a retrospective cohort study of 10\u00a0505\u00a0818 Korean subjects who received health checkups in 2009\u20132012. Patients were classified into a MetS and its components group and were followed\u2010up until 2016 for new\u2010onset BD. A Cox proportional hazards model was used to assess the independent or synergistic effects of MetS and its components on the risk of incident BD. Compared to subjects without MetS components, the hazard ratio (HR) for development of BD in patients with MetS was 0.874 (95% confidence interval [CI]: 0.819\u20130.933) and this association was more prominent when all components of MetS were present (HR\u00a0=\u00a00.675, 95% CI\u00a0=\u00a00.571\u20130.798). Subjects with low high density lipoprotein (HDL) has a significantly increased risk of the development of BD (HR\u00a0=\u00a01.51, 95% CI\u00a0=\u00a01.4\u20131.594) compared to controls. This study showed that the incidence of Beh\u00e7et's disease was reduced in subjects with MetS. Moreover, the presence of MetS components, with the exception of HDL, was negatively related to the development of BD.<\/jats:p>","DOI":"10.1111\/1346-8138.15809","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T01:12:07Z","timestamp":1620522727000},"page":"1062-1066","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between metabolic syndrome and Beh\u00e7et's disease: A nationwide population\u2010based study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3671-502X","authenticated-orcid":false,"given":"JiHyun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Dermatology Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul 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