{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:00:03Z","timestamp":1792684803400,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Individuals who used skin\u2010whitening cosmetics (quasi\u2010drugs) containing 2% rhododendrol\u2010containing agents, developed leukoderma at a higher frequency than those who have used other skin\u2010whitening cosmetics. The Rhododenol Research Team (RD\u2010Team) was formed and commissioned by Kanebo Cosmetics Inc. to conduct research in treatments of rhododendrol\u2010induced leukoderma (RDL), to evaluate effective treatment options from a medical standpoint, and provide information to a wide range of people. In this study, we evaluated the efficacy of various treatments for RDL from a medical perspective, based on the information published in the literature as original or review articles. We searched the PubMed (international) and the Igaku Chuo Zasshi (ICHUSHI) (Japanese) databases using the keywords \u201cRhododenol\u201d and \u201crhododendrol\u201d, for articles published between July 2013 and November 2020. We discuss the main clinical findings and treatments (topical, oral, phototherapy, and surgical) of this condition based on the literature review. We found that ultraviolet light therapy is the most effective treatment for RDL. We have also summarized reports of the efficacy of oral vitamin D3 in RDL. A topical prostaglandin derivative has been reported in a new study to be effective. We have provided guidance for patients using self\u2010tanning and skin\u2010whitening agents to improve their quality of life. Finally, we have highlighted the importance of providing patients with information on contact dermatitis and instructing them to discontinue product use immediately if they develop any symptoms of contact dermatitis while using skin\u2010whitening agents.<\/jats:p>","DOI":"10.1111\/1346-8138.15835","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T04:35:31Z","timestamp":1615264531000},"page":"961-968","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Rhododendrol\u2010induced leukoderma update I: Clinical findings and treatment"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5096-3006","authenticated-orcid":false,"given":"Kayoko","family":"Matsunaga","sequence":"first","affiliation":[{"name":"Department of Integrative Medical Science for Allergic Disease Fujita Health University School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8367-1034","authenticated-orcid":false,"given":"Kayoko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Allergology Fujita Health University School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6967-0710","authenticated-orcid":false,"given":"Akiko","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Integrative Medical Science for Allergic Disease Fujita Health University School of Medicine Nagoya Japan"},{"name":"Departent of Dermatology Nagata Clinic Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5239-8474","authenticated-orcid":false,"given":"Atsushi","family":"Tanemura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Course of Integrated Medicine Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0903-873X","authenticated-orcid":false,"given":"Yuko","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Yamagata University Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4669-9721","authenticated-orcid":false,"given":"Tamio","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Yamagata University Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momoko","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sapporo Medical University School of Medicine Sapporo 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"2255","article-title":"Review report 2018 on Rhododenol\u2010induced leukoderma","volume":"128","author":"Matsunaga K","year":"2018","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_7_3_1","first-page":"2095","article-title":"The first epidemiological report of Rhododenol\u2010induced leukoderma in Japan based on a nationwide survey","volume":"124","author":"Aoyama Y","year":"2014","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_7_4_1","first-page":"3125","article-title":"The second epidemiological report of Rhododenol\u2010induced leukoderma in Japan based on a nationwide survey","volume":"124","author":"Suzuki K","year":"2014","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_7_5_1","first-page":"2401","article-title":"The third epidemiological report of Rhododenol\u2010induced leukoderma in Japan based on a 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