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Its effects on itching and disease severity were examined with Numerical Rating Scale\u2013Itch (NRS\u2010I), Eczema Area and Severity Index (EASI), and Investigator Global Assessment (IGA) scores; body surface areas (BSA); and thymus\u2010 and activation\u2010regulated chemokine (TARC), total immunoglobulin (Ig)E, and eosinophil levels. NRS\u2010I scores, EASI scores, TARC levels, and total IgE levels before dupilumab treatment were not statistically different between the prurigo and non\u2010prurigo groups. With dupilumab treatment, NRS\u2010I scores, EASI scores, IGA scores, BSA, TARC levels, and total IgE levels were significantly reduced from baseline in both groups at 1\u20132\u00a0months and onward, but skin symptom improvement in the prurigo group was slower than in the non\u2010prurigo group, as evidenced by significantly higher EASI scores, BSA, and TARC levels at several time points during the 12\u00a0months of dupilumab treatment. Prurigo patients were slower in EASI\u201050 achievement and significantly lower in EASI\u201090 achievement at 12\u00a0months than non\u2010prurigo patients. Adherence to dupilumab was not different, but total equivalent amounts of concomitant therapeutic agents (corticosteroids and tacrolimus) used during dupilumab treatment were significantly higher in the prurigo group (median, 56.2\u00a0g\/week) than in the non\u2010prurigo group (median, 33.7\u00a0g\/week). There were 2.2 adverse events per patient on average; ocular complaints were most frequent. Dupilumab was effective in treating intractable prurigo, but despite significantly greater concomitant therapeutic agent use, skin symptom improvement was slower in prurigo patients than in non\u2010prurigo patients.<\/jats:p>","DOI":"10.1111\/1346-8138.15843","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T10:43:04Z","timestamp":1616236984000},"page":"638-644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Dupilumab shows slow, steady effectiveness for intractable prurigo in patients with atopic dermatitis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9557-9526","authenticated-orcid":false,"given":"Satoshi","family":"Takeuchi","sequence":"first","affiliation":[{"name":"Department of Dermatology Federation of National Public Service Personnel Mutual Aid Associations Hamanomachi Hospital Fukuoka Japan"},{"name":"Department of 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