{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T09:29:05Z","timestamp":1751448545536,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T00:00:00Z","timestamp":1618272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Severe digital ischemia (SDI), which presents with digital ulcers, necrosis, or gangrene, has been reported to be a rare manifestation of anti\u2010aminoacyl transfer RNA synthetase (ARS) antibody\u2010positive polymyositis\/dermatomyositis or anti\u2010synthetase syndrome. A retrospective study was conducted between 2009 and 2020 at our department to investigate the clinical features of anti\u2010ARS antibody\u2010positive patients with SDI and identify their predictors. A total of 46 patients who were positive for anti\u2010ARS antibody were included, four of whom (8.7%) presented with SDI. The characteristics of the patients with SDI were as follows: the median age was 74\u00a0years, with 75% being female; anti\u2010Jo\u20131 antibody, Raynaud's phenomenon, interstitial lung disease, and myositis were observed in two (50%), four (100%), four (100%), and three patients (75%), respectively. Next, we reviewed the literature of anti\u2010ARS antibody\u2010positive patients with SDI and investigated the predictors of SDI by analyzing a total of 51 patients, including the previously reported five patients with SDI. Multivariable analyses revealed that Raynaud's phenomenon and myositis independently predicted the development of SDI in patients with anti\u2010ARS antibody. In conclusion, digital ulcers, necrosis, or gangrene seem to be more common presentations in our study, and Raynaud's phenomenon and myositis can predict the complications of SDI in anti\u2010ARS antibody\u2010positive patients.<\/jats:p>","DOI":"10.1111\/1346-8138.15884","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T11:50:09Z","timestamp":1618314609000},"page":"1044-1051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The clinical characteristics and predictors of severe digital ischemia in patients with anti\u2010aminoacyl transfer RNA synthetase antibodies"],"prefix":"10.1111","volume":"48","author":[{"given":"Harumichi","family":"Suma","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology Hiroshima University Hospital Hiroshima 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Kyoto University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology Hiroshima University Hospital Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Hosokawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology Hiroshima University Hospital Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michinori","family":"Ishitoku","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology Hiroshima University Hospital Hiroshima 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