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Psoriasis affects approximately 2% of the population worldwide, and dramatic advances have been achieved in the understanding and treatment options for psoriasis. Recent progress in biological therapies has revealed the fundamental roles of tumor necrosis factor\u2010\u03b1, interleukin (IL)\u201023p19, and the IL\u201017A axis together with skin\u2010resident immune cells and major signal transduction pathways in the pathogenesis of psoriasis. In addition to IL\u201017\u2010producing T helper17 cells, innate lymphoid cell (ILC)3 induces psoriasis rashes directly without T\u2010cell\/antigen interaction in response to the released antimicrobial peptides from activated keratinocytes and inflammatory cytokines. ILC3 typically expresses retinoic acid receptor\u2010related orphan receptor gamma t in the nucleus, matures in the presence of IL\u20107 and IL\u201023, and produces IL\u201017 and IL\u201022. The number of ILC3s is increased in the blood, psoriasis rash, and even in nonrash areas of psoriatic skin. Psoriasis is significantly associated with cardiovascular disease, metabolic syndrome, and inflammatory disorders, particularly the severe type. The similarity of enterobacteria in the psoriasis gut to that in diabetic patients may be related to its pathogenesis. In the current review, we focus on the pathophysiology of psoriasis in the accelerated immunological inflammatory loop, danger signal from keratinocytes, and cytokines, particularly IL\u201017 and IL\u201023p19. In addition, pathophysiological speculation with regard to morphology has been supplemented. Finally, the differences and similarities between psoriasis and atopic dermatitis are discussed.<\/jats:p>","DOI":"10.1111\/1346-8138.15913","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T21:08:06Z","timestamp":1619125686000},"page":"722-731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":197,"title":["Pathophysiology of psoriasis: A review"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3055-5202","authenticated-orcid":false,"given":"Keiichi","family":"Yamanaka","sequence":"first","affiliation":[{"name":"Department of Dermatology Mie University Graduate School of Medicine Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine of Sensory and Motor Organs Faculty of Medicine Tottori University Yonago 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