{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:13:37Z","timestamp":1785392017329,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T00:00:00Z","timestamp":1619308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Verrucous epidermal nevus (VEN) is a benign skin disease that seriously affects appearance. Numerous therapeutic methods have been tried with varying results. However, there are few reports on the treatment of VEN by photodynamic therapy (PDT). This study aimed to evaluate the efficacy and adverse effects of 5\u2010aminolevulinic acid (ALA)\u2010PDT in VEN treatment with a long\u2010term follow\u2010up. A total of 16 patients with VEN received ALA\u2010PDT and were followed up for more than 1\u00a0year to observe the treatment effects, adverse reactions, and patients\u2019 satisfaction. Complete improvement of lesions was observed in 11 patients (three to six sessions of ALA\u2010PDT). Two patients obtained 90\u201399% improvement (five sessions) and 50\u201389% improvement in three patients (three to six sessions). They were satisfied with the treatment effects, with an average satisfaction of 4.19\/5 (\u00b10.91). Long\u2010term follow\u2010up ranging 14\u201350\u00a0months showed a low recurrence rate (2\/16) and no scar left after ALA\u2010PDT. The results demonstrate that ALA\u2010PDT is an effective and safe therapy in treating VEN with mild adverse reactions and a low risk of scar formation.<\/jats:p>","DOI":"10.1111\/1346-8138.15923","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T17:24:23Z","timestamp":1619371463000},"page":"1229-1235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Safety and effectiveness of 5\u2010aminolevulinic acid photodynamic therapy combined with fractional micro\u2010plasma radio\u2010frequency treatment for verrucous epidermal nevus: A retrospective study with long\u2010term follow\u2010up"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9313-1357","authenticated-orcid":false,"given":"Siqi","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Nanfang Hospital Southern Medical University Guangzhou 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