{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:20:23Z","timestamp":1747182023842,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Papuloerythroderma (PEO) is a representative form of senile erythroderma with an unclear pathogenesis. This study aimed to characterize the T\u2010cell phenotypes responsible for the pathogenesis of PEO. Cytokine profiles and cutaneous lymphocyte antigen (CLA) expression on circulating T lymphocytes in patients with PEO were simultaneously analyzed using flow cytometry. The patients with PEO showed significantly higher circulating interleukin (IL)\u20104\u2010, IL\u201013\u2010, IL\u201022\u2010, and IL\u201031\u2010producing CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T\u2010cell levels than healthy subjects. However, their levels significantly decreased after remission of PEO. No difference was observed in the proportions of circulating interferon (IFN)\u2010\u03b3\u2010 and IL\u201017\u2010producing CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T cells between the patients with PEO and healthy subjects. In particular, the proportion of circulating IL\u20104\u2010, IL\u201013\u2010, IL\u201022\u2010, and IL\u201031\u2010producing CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T cells was much higher in the CLA<jats:sup>+<\/jats:sup> subset than in the CLA<jats:sup>\u2013<\/jats:sup> subset. There was a positive correlation between IL\u201013\u2010, IL\u201022\u2010, and IL\u201031\u2010producing CD4<jats:sup>+<\/jats:sup> T cells and the disease severity score of PEO. Moreover, a positive correlation was also observed between the proportion of IL\u201022\u2010 or IL\u201031\u2010producing cells and circulating IL\u201013\u2010producing cells in both CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T cells, and approximately 50% of both IL\u201022\u2010 and IL\u201031\u2010producing CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T cells coproduced IL\u201013. IL\u201013\/IL\u201022\/IL\u201031 skewing within the skin\u2010homing T\u2010cell population may be involved in the pathogenesis of PEO.<\/jats:p>","DOI":"10.1111\/1346-8138.15937","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T11:48:12Z","timestamp":1621338492000},"page":"1357-1364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Interleukin (IL)\u201013\/IL\u201022\/IL\u201031 skewing within the skin\u2010homing T\u2010cell population in papuloerythroderma"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6614-8492","authenticated-orcid":false,"given":"Saori","family":"Takamura","sequence":"first","affiliation":[{"name":"Department of Dermatology Saitama Medical Center Saitama Medical University Saitama 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