{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:34:51Z","timestamp":1789684491571,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Xerosis and pruritus are common in patients undergoing dialysis. These symptoms are treated with moisturizers, but limited evidence supports the efficacy of such treatment. Our exploratory study suggested the effectiveness of a heparinoid\u2010containing product for xerosis in dialysis patients. We conducted a multicenter, open\u2010label, randomized, before\u2010after, parallel\u2010group comparative study to verify the exploratory study results (Clinical Trial Registry: UMIN000029360). Seventy\u2010one Japanese patients undergoing dialysis with chronic kidney disease and xerosis were randomly assigned to receive a heparinoid\u2010containing product for 2\u00a0weeks (group A [\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a036]) or 8\u00a0weeks (group B [\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a035]). Patients were instructed to apply the study product based on the fingertip unit method. The efficacy endpoints were the water content of the stratum corneum (WCSC), skin dryness score, pruritus visual analog scale score, and Dermatology Life Quality Index. Safety was assessed by monitoring adverse events. The mean WCSC (arbitrary units) was 26.0\u00a0\u00b1\u00a09.6 in group A and 25.2\u00a0\u00b1\u00a010.0 in group B at the start of treatment (week 0), significantly increased to 39.0\u00b112.5 in group A and 38.5\u00a0\u00b1\u00a011.0 in group B (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001 for both vs week 0) by week 2, and then decreased only in group A. Thus, the WCSC at week 4 (the primary endpoint) remained significantly higher in group B (36.4\u00a0\u00b1\u00a012.2 vs 28.8\u00a0\u00b1\u00a010.4;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.0068). Other endpoints improved during treatment with the study product. One patient developed a rash and erythema as treatment\u2010related adverse events. In conclusion, 8\u00a0weeks\u2019 application of a heparinoid\u2010containing product was effective for xerosis in patients undergoing dialysis.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.15950","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:19:09Z","timestamp":1622074749000},"page":"1327-1335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy of a moisturizer for pruritus accompanied by xerosis in patients undergoing dialysis: A multicenter, open\u2010label, randomized verification study"],"prefix":"10.1111","volume":"48","author":[{"given":"Yukie","family":"Yoshida","sequence":"first","affiliation":[{"name":"Kidney Disease Clinic of Nippon Medical School Bunkyo\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Hirama","sequence":"additional","affiliation":[{"name":"Kidney Disease Clinic of Nippon Medical School Bunkyo\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumasa","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Kidney Disease Clinic of Nippon Medical School Bunkyo\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Nephrology Koyama Memorial Hospital Kashima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noritsugu","family":"Yokota","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Moka Hospital Moka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1095-0355","authenticated-orcid":false,"given":"Hidehisa","family":"Saeki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nippon Medical School Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momoyo","family":"Kishida","sequence":"additional","affiliation":[{"name":"Medical Affairs Department Maruho Co., Ltd. Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Medical Affairs Department Maruho Co., Ltd. Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Kanakubo","sequence":"additional","affiliation":[{"name":"Medical Affairs Department Maruho Co., Ltd. Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2918-4435","authenticated-orcid":false,"given":"Shuichi","family":"Tsuruoka","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nippon Medical School Bunkyo\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000485156"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962011000200015"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.454"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.2018.37.2.138"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4103\/njcp.njcp_270_18","article-title":"Skin changes and dermatological life quality index in chronic kidney disease patients in a tertiary hospital in Southern Nigeria","volume":"22","author":"Adejumo OA","year":"2019","journal-title":"Niger J Clin Pract"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00100110"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3125"},{"key":"e_1_2_8_10_1","first-page":"275","article-title":"Characteristics of cutaneous manifestations in dialysis patients \u2013 a focus on dry skin","volume":"75","author":"Kawashima M","year":"2013","journal-title":"Kidney Dial"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03280317"},{"key":"e_1_2_8_12_1","first-page":"136","article-title":"Uremic pruritus in patients on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD). The role of plasma histamine and skin mast cells","volume":"34","author":"Mettang T","year":"1990","journal-title":"Clin Nephrol"},{"key":"e_1_2_8_13_1","first-page":"1589","article-title":"Clinical practice guidelines for the management of pruritus 2020","volume":"130","author":"Sato T","year":"2020","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2019.04.008"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1991.tb01232.x"},{"key":"e_1_2_8_16_1","first-page":"311","article-title":"Evaluation of an optimal method for topical application of moisturizer","volume":"5","author":"Nakamura M","year":"2006","journal-title":"Skin Research"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12179"},{"key":"e_1_2_8_18_1","first-page":"2763","article-title":"Review of asteatosis (dry skin) \u2013 Definition and treatment consideration of asteatosis","volume":"129","author":"Kikuchi K","year":"2019","journal-title":"Jpn J Dermatol"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.15950","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.15950","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.15950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T03:24:48Z","timestamp":1693279488000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.15950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,26]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/1346-8138.15950"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.15950","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,26]]},"assertion":[{"value":"2020-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}