{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T22:48:16Z","timestamp":1767998896708,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673064"],"award-info":[{"award-number":["81673064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730085"],"award-info":[{"award-number":["81730085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>IgE autoantibodies targeting BP230 can be identified in 38%\u201368% of bullous pemphigoid (BP) patients, yet the diagnostic and pathogenic value of anti\u2010BP230 IgE still remains inconclusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We intend to investigate the clinical and immunological characteristics of anti\u2010BP230 IgE in BP patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Fifty\u2010four BP patients were divided into two groups based on the responsiveness of a topical steroid. We investigated clinical features and IgE autoantibodies profiles by indirect immunofluorescence, ELISA and western blot between the two groups. BP disease area index (BPDAI) scores, total IgE, peripheral eosinophil counts, and anti\u2010BP230 IgE level were significantly higher in the topical\u2010steroid\u2010resistant group. The majority of topical\u2010steroid\u2010resistant patients present with blister\/erythematous phenotype (64.3%) and anti\u2010BP230 IgE (59.5%), which correlates with total IgE levels. ELISAs of domain\u2010specific BP230 recombinant proteins indicated that IgE in the topical\u2010steroid\u2010resistant group can react with all seven domains of BP230 and more frequently with the BP230\u2010R1 epitope.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anti\u2010BP230 IgE is more frequently observed in topical\u2010steroid\u2010therapy\u2010resistant patients and the prefers R1 domain of BP230, which is not included in commercially available testing kits. Our study further suggests the pathogenic role of anti\u2010BP230 IgE in BP. Performing anti\u2010BP230 IgE detection can serve as an indicator for initiating systemic steroid therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1346-8138.15952","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T06:39:19Z","timestamp":1623739159000},"page":"1372-1380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["BP230 IgE autoantibodies in topical\u2010steroid\u2010resistant bullous pemphigoid"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5424-1331","authenticated-orcid":false,"given":"Yen\u2010chi","family":"Shih","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Medicine Ruijin Hospital Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijie","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of 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