{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T15:03:37Z","timestamp":1774710217623,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:00:00Z","timestamp":1621555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Stevens\u2013Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are fatal adverse skin reactions characterized by high fever, epidermal detachment, and mucositis. It is well known that SJS\/TEN occasionally affects various organs, leading to permanent damage and death in some patients. Although acute liver dysfunction is a relatively common complication of SJS\/TEN, severe acute liver dysfunction requiring liver transplantation is rare. We present the case of a 14\u2010year\u2010old girl with SJS complicated by severe and rapidly progressive liver dysfunction, specifically, acute liver failure (ALF) requiring liver transplantation. A lymphocyte transformation test showed positive results for acetaminophen and cefdinir. Furthermore, human leukocyte antigen (HLA) genotyping revealed the presence of the HLA\u2010A*02:06 genotype, which is reported to be strongly associated with acetaminophen\u2010related SJS\/TEN with severe ocular complications. These results suggested that our patient may have presented with acetaminophen\u2010induced SJS complicated by ALF, but no ocular complications. This is the first report of a pediatric patient with SJS who required liver transplantation. In rare instances, severe liver dysfunction requiring liver transplantation should be considered as a possible complication of SJS\/TEN.<\/jats:p>","DOI":"10.1111\/1346-8138.15963","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T11:20:35Z","timestamp":1621596035000},"page":"1423-1427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A pediatric case of Stevens\u2010Johnson syndrome with acute liver failure, resulting in liver transplantation"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1478-2897","authenticated-orcid":false,"given":"Michiru","family":"Totsuka","sequence":"first","affiliation":[{"name":"Department of Dermatology Yokohama City University School of Medicine Yokohama 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