{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:57:02Z","timestamp":1791863822977,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The neutrophil\u00a0:\u00a0lymphocyte ratio (NLR), platelet\u00a0:\u00a0lymphocyte ratio (PLR), C\u2010reactive protein\u00a0:\u00a0albumin ratio (CAR), and albumin\u00a0:\u00a0fibrinogen ratio (AFR) have been considered as useful inflammatory biomarkers. However, their roles in Stevens\u2013Johnson Syndrome (SJS)\/toxic epidermal necrolysis (TEN) still remain unclear. This study aimed to test whether NLR, PLR, CAR, and AFR serve as predictive markers of disease severity and systemic inflammation in patients with SJS\/TEN. This retrospective study included 40 patients with SJS\/TEN and 60 healthy controls. The correlation between these markers and severity\u2010of\u2010illness score for toxic epidermal necrolysis (SCORTEN), ABCD\u201010, procalcitonin (PCT), C\u2010reactive protein (CRP) were analyzed and compared. Univariable and multivariable analysis were used to assess associations of variables with mortality. The receiver\u2013operator curves (ROC) were used to evaluate the predictive value of variables for mortality in SJS\/TEN patients. The results demonstrated that the NLR and PLR of SJS\/TEN patients were significantly higher and the AFR was significantly lower when compared with healthy controls (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The NLR and CAR were positively correlated with SCORTEN, ABCD\u201010, PCT, and CRP. The NLR in SCORTEN of \u22653 group was significantly higher than that in SCORTEN &lt;3 group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) and there were no significant differences between PLR, CAR, and AFR between the two groups. The univariate analysis suggested that NLR of &gt;5.79 was a risk factor for mortality (odds ratio, 10.5; <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05), but the association was no longer statistically significant in multivariable analysis. The ROC showed that NLR had a sensitivity of 85.7% and specificity of 63.6% for predicting death with a cut\u2010off value of 5.79 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) in SJS\/TEN patients. In conclusion, among the four markers, NLR and CAR can partially reflect severity and inflammatory status in patients with SJS\/TEN. NLR was also a predictor of death.<\/jats:p>","DOI":"10.1111\/1346-8138.15968","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T20:18:16Z","timestamp":1622578696000},"page":"1394-1400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Neutrophil\u00a0:\u00a0lymphocyte ratio is associated with disease severity and mortality in patients with Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6052-9665","authenticated-orcid":false,"given":"Qian","family":"Wang","sequence":"first","affiliation":[{"name":"The Institute of Dermatology and Venereology Sichuan Provincial People\u2019s Hospital University of Electronic Science and Technology of China Chengdu China"},{"name":"Academy of Sciences Sichuan Translational Medicine Research Hospital Chengdu 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