{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T11:49:54Z","timestamp":1771674594111,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Keratinocytes are the main targets of infiltrating T cells in the pathogenesis of lichen planus. However, the mechanisms of dense inflammatory infiltrates beneath the epidermis remain unknown. The aim of the present study was to clarify the roles of programmed cell death 1 (PD\u20101) and its ligand (PD\u2010L1) in the pathogenesis of lichen planus. Immunohistochemistry of PD\u20101 and PD\u2010L1 in 12 cases each of lichen planus and dermal\u2010type erythema multiforme was performed. The expression of PD\u20101 and PD\u2010L1 on infiltrating inflammatory cells, predominantly lymphocytes in lichen planus, was significantly less compared to that in dermal\u2010type erythema multiforme. By dual immunofluorescence, the overlap between PD\u20101 and leukocyte common antigen, CD4, CD8, CD68, and factor XIIIa was limited and found in only a very small portion of lichen planus cells. Our data suggest that decreased expression of PD\u20101 and PD\u2010L1 could play a role in accelerating inflammatory cell infiltration targeting the epidermis in the pathogenesis of lichen planus.<\/jats:p>","DOI":"10.1111\/1346-8138.15977","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T14:55:53Z","timestamp":1623077753000},"page":"1428-1432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reduced expression of programmed cell death 1 and programmed cell death ligand 1 in infiltrating inflammatory cells of lichen planus without administration of immune checkpoint inhibitors"],"prefix":"10.1111","volume":"48","author":[{"given":"Kazufumi","family":"Shirouchi","sequence":"first","affiliation":[{"name":"Department of Dermatology, School of Medicine Showa University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Koshikawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine Showa University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Shinya","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine Showa University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9367-5167","authenticated-orcid":false,"given":"Hideaki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine Showa University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Medical Education, School of Medicine Showa University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Clinical Immuno\u2010Oncology Clinical Research Institute of Clinical Pharmacology and Therapeutics School of Medicine Showa University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5691-7211","authenticated-orcid":false,"given":"Hirohiko","family":"Sueki","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine Showa University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1973.01620210008002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01891881"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxm057"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.7.1027"},{"key":"e_1_2_6_6_1","unstructured":"AiharaM.Investigation of skin damage and prevention of worsening by new molecular targeted drugs. 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