{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:41:37Z","timestamp":1758400897982,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T00:00:00Z","timestamp":1623369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pachydermoperiostosis (PDP) is a genetic disease characterized by digital clubbing, periostosis, and pachydermia caused by mutated <jats:italic>HPGD<\/jats:italic> or <jats:italic>SLCO2A1<\/jats:italic>. Plasma prostaglandin (PG)E<jats:sub>2<\/jats:sub> levels are increased in these patients. However, other eicosanoids have not been quantitated. We aimed to quantitate plasma eicosanoid levels in four patients carrying <jats:italic>SLCO2A1<\/jats:italic> mutations by high\u2010performance liquid chromatography\u2013tandem mass spectrometry. PGE<jats:sub>2<\/jats:sub> level was elevated in all patients; PGD<jats:sub>2<\/jats:sub> and 11\u03b2\u2010PGF<jats:sub>2<\/jats:sub>\u03b1 levels were also increased in some patients, whereas eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid levels were decreased in all patients. Our data indicate a dysfunctional eicosanoid homeostasis and varied levels of PG in patients with a complete form of PDP carrying <jats:italic>SLCO2A1<\/jats:italic> mutations. PGE<jats:sub>2<\/jats:sub> levels seem to mostly affect the symptoms, with other eicosanoids possibly having a minor effect.<\/jats:p>","DOI":"10.1111\/1346-8138.16012","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T11:38:10Z","timestamp":1623411490000},"page":"1442-1446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Eicosanoid profiling in patients with complete form of pachydermoperiostosis carrying <i>SLCO2A1<\/i> mutations"],"prefix":"10.1111","volume":"48","author":[{"given":"Tomohiro","family":"Oiwa","sequence":"first","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-4828","authenticated-orcid":false,"given":"Mami","family":"Ishibashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan"},{"name":"Department of Dermatology Kitano Hospital Tazuke Kofukai Medical Research Institute Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0270-5744","authenticated-orcid":false,"given":"Toshiaki","family":"Okuno","sequence":"additional","affiliation":[{"name":"Department of Biochemistry (I) Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Ohba","sequence":"additional","affiliation":[{"name":"Department of Biochemistry (I) Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9152-7662","authenticated-orcid":false,"given":"Yuichiro","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9546-9869","authenticated-orcid":false,"given":"Ryuji","family":"Uozumi","sequence":"additional","affiliation":[{"name":"Institute for Advancement of Clinical and Translational Science (iACT) Koto University Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5848-128X","authenticated-orcid":false,"given":"Feras M.","family":"Ghazawi","sequence":"additional","affiliation":[{"name":"Division of Dermatology University of Ottawa Ottawa Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8128-1849","authenticated-orcid":false,"given":"Kazue","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Surgical Subspecialties National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3261-2047","authenticated-orcid":false,"given":"Hironori","family":"Niizeki","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Surgical Subspecialties National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5219-1553","authenticated-orcid":false,"given":"Takehiko","family":"Yokomizo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry (I) Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4004-1339","authenticated-orcid":false,"given":"Takashi","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0773-0554","authenticated-orcid":false,"given":"Kenji","family":"Kabashima","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan"},{"name":"A*STAR Singapore Immunology Network (SIgN)\/Skin Research Institute of Singapore (SRIS) Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2005.00533.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.153"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-6980(02)00050-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.11.019"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2012.07.008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2017.06.001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2017.09.015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-017-0163-8"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12869"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2014.05.008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.06.026"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M037754"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.08.001"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15336"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.16012","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.16012","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.16012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T07:26:16Z","timestamp":1693293976000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.16012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,11]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/1346-8138.16012"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.16012","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"type":"print","value":"0385-2407"},{"type":"electronic","value":"1346-8138"}],"subject":[],"published":{"date-parts":[[2021,6,11]]},"assertion":[{"value":"2021-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}