{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:24:51Z","timestamp":1789604691237,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T00:00:00Z","timestamp":1625788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The prevalence of primary axillary hyperhidrosis in Japan is 5.75% (males, 6.60%; females, 4.72%) in the population aged 5\u201364\u00a0years. No study on comprehensively evaluated direct medical costs, hygiene product costs, and productivity loss in axillary hyperhidrosis patients has been published in Japan. The aim of this study was to estimate the cost of illness for axillary hyperhidrosis in Japan by conducting a nationwide insurance claims database analysis and a cross\u2010sectional Web\u2010based survey. Among patients diagnosed with primary axillary hyperhidrosis at least once between November 2012 and October 2019, health insurance receipt data of 1447 patients were analyzed. A cross\u2010sectional Web\u2010based survey was conducted on 321 patients aged 16\u201359\u00a0years with axillary hyperhidrosis to calculate hygiene product costs and productivity loss using a Work Productivity and Activity Impairment questionnaire. Furthermore, nationwide estimation was performed for the hygiene product costs and productivity loss based on the number of patients estimated from the prevalence. The annual direct medical costs per axillary hyperhidrosis patient were \u00a591\u00a0491 in 2016, \u00a593\u00a0155 in 2017, and \u00a575\u00a0036 in 2018. In all of these years, botulinum toxin type A injection accounted for approximately 90% of the total costs. The annual total cost of hygiene products per axillary hyperhidrosis patient was \u00a59325. The overall work impairment (%) of working patients with axillary hyperhidrosis was 30.52%, and its monthly productivity loss was \u00a5120\u00a0593\/patient. The activity impairment (%) of full\u2010time housewives with axillary hyperhidrosis was 49.05% and its monthly productivity loss was \u00a5176\u00a0368\/patient. The annual hygiene product cost based on the nationwide estimation was \u00a524.5\u00a0billion and the monthly productivity loss was \u00a5312\u00a0billion. The significant cost associated with axillary hyperhidrosis was clarified. If out\u2010of\u2010pocket expenses for treatments not covered by health insurance are included in the estimation, the cost will further increase.<\/jats:p>","DOI":"10.1111\/1346-8138.16050","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T05:40:56Z","timestamp":1625895656000},"page":"1482-1490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cost\u2010of\u2010illness study for axillary hyperhidrosis in Japan"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0450-1377","authenticated-orcid":false,"given":"Hiroyuki","family":"Murota","sequence":"first","affiliation":[{"name":"Department of Dermatology Nagasaki University Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Ikebukuro Nishiguchi Fukurou Dermatology Clinic Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Oshima","sequence":"additional","affiliation":[{"name":"Department of Dermatology Aichi Medical University School of Medicine Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Tamada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Aichi Medical University School of Medicine Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9603-9679","authenticated-orcid":false,"given":"Takeshi","family":"Yanagishita","sequence":"additional","affiliation":[{"name":"Department of Dermatology Aichi Medical University School of Medicine Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Murayama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nagasaki University Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1198-731X","authenticated-orcid":false,"given":"Sachie","family":"Inoue","sequence":"additional","affiliation":[{"name":"CRECON Medical Assessment Inc. 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Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5773-9485","authenticated-orcid":false,"given":"Hiroo","family":"Yokozeki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12258"},{"key":"e_1_2_7_3_1","volume-title":"Health care cost, quality, and outcomes: ISPOR Book of terms","author":"Berger ML","year":"2003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2014.20.4.327"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7245.1335"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ip.6.3.177"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/2191-1991-2-18"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17203"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737167.2021.1895753"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijdvl.IJDVL_333_18"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2019.04.007"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.040"},{"key":"e_1_2_7_13_1","unstructured":"YokozekiH.Epidemiological survey of idiopathic focal hyperhidrosis \u2010 Pathological analysis by cerebral blood flow scintigraphy and establishment of treatment guidelines. 2009 Ministry of Health Labour and Welfare\u2019s Health and Labour Sciences Research Grant (Research Project for Overcoming Intractable Diseases).2010."},{"key":"e_1_2_7_14_1","unstructured":"JMDC Inc.https:\/\/www.jmdc.co.jp\/. 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