{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:09:08Z","timestamp":1773655748037,"version":"3.50.1"},"reference-count":7,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dipeptidyl peptidase 4 inhibitors (DPP\u20104i) are associated with an increased risk of developing bullous pemphigoid (BP) in patients with diabetes. Autoantibodies targeting epitopes on the processed BP180, 120\u2010kDa (LAD\u20101), and 97\u2010kDa (LABD97) linear immunoglobulin (Ig)A dermatosis antigens are the major autoantibodies in DPP\u20104i\u2010associated BP. However, no case of mucous membrane pemphigoid (MMP) developing during treatment with DPP\u20104i has been reported. We report a case of MMP associated with DPP\u20104i. A man in his late 70s presented with oral mucous membrane erosion and a few blisters on his upper chest and back. He had used linagliptin for diabetes for over 1\u00a0year when he presented. The immunological characteristics were similar to DPP4i\u2010associated BP: higher reactivity to LAD\u20101 and LABD97 than to the full\u2010length BP180. The aphthae achieved remission after oral linagliptin was replaced with sitagliptin. However, 6\u00a0months later, the aphthae relapsed and any DPP\u20104i was discontinued. The aphthae disappeared, and now he is completely free from lesions associated with MMP. This case suggests that the DPP\u20104i may have shared roles in the production of IgG antibodies to LAD\u20101 or to LABD97 in the pathogenesis of DPP\u20104i\u2010associated BP and MMP. Our case highlights the possibility of overlooking the mild MMP in DPP\u20104i\u2010treated diabetes patients with mucosal lesions.<\/jats:p>","DOI":"10.1111\/1346-8138.16061","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T19:38:35Z","timestamp":1626377915000},"page":"1584-1587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Dipeptidyl peptidase 4 inhibitor\u2010associated mucous membrane pemphigoid"],"prefix":"10.1111","volume":"48","author":[{"given":"Mei","family":"Suezawa","sequence":"first","affiliation":[{"name":"School of Medicine Kagawa University Faculty of Medicine Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9497-0029","authenticated-orcid":false,"given":"Teruki","family":"Dainichi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kagawa University Faculty of Medicine Kagawa 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