{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T22:01:27Z","timestamp":1779400887585,"version":"3.53.1"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Specific studies on apremilast for nail psoriasis are lacking. Our objective was to evaluate the nail\u2010specific patient\u2010reported outcomes, clinical efficacy, ultrasound (US) parameters, and safety of apremilast for nail psoriasis. We conducted a prospective cohort study including adult patients with plaque and nail psoriasis with a fingernail Nail Psoriasis Severity Index (NAPSI) score of 12 or more. Patients were treated with apremilast 30\u00a0mg b.i.d. for 52\u00a0weeks. Forty\u2010five patients were included. At week 52, the Nail Assessment in Psoriasis and Psoriatic Arthritis (NAPPA) Patient Benefit Index global weighted score was 2 or more in 52% of patients and NAPPA Quality of Life and fingernail NAPSI improved by 57% and 53%, respectively. US parameters improved from week 16 onwards. Target nail NAPSI improvements were higher for nail matrix scores (60%) than for nail bed scores (38%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Baseline target nail bed NAPSI was associated with not achieving a target nail 50% reduction in NAPSI score at week 52 in the bivariate analysis (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.024). Safety was consistent with the known apremilast profile. Results from apremilast therapy for 52\u00a0weeks in patients with psoriasis and predominant nail disease show significant improvements in nail\u2010specific quality of life, clinical signs, and structural restoration on US, suggesting that apremilast may be considered in the treatment of nail psoriasis.<\/jats:p>","DOI":"10.1111\/1346-8138.16074","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T05:30:59Z","timestamp":1628832659000},"page":"1593-1596","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Apremilast improves quality of life and ultrasonography parameters in patients with nail psoriasis: A prospective cohort study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3721-8030","authenticated-orcid":false,"given":"Carlos","family":"Mu\u00f1oz\u2010Santos","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital General de Granollers Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7911-8428","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Sola\u2010Ortigosa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General de Granollers Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7979-5031","authenticated-orcid":false,"given":"David","family":"Vidal","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Moises Broggi Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3520-2169","authenticated-orcid":false,"given":"Antonio","family":"Guilabert","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General de Granollers Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09831.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000246274"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.03.049"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14164"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.09.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.11152\/mu-1327"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04748-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170146"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes014"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1623-z"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12664"},{"key":"e_1_2_7_13_1","unstructured":"The Jamovi project.jamovi. 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