{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:36:32Z","timestamp":1787877392219,"version":"build-2784847793"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Photochemotherapy with psoralen and ultraviolet A (PUVA) is widely used for refractory skin diseases. Bathwater delivery of 8\u2010methoxypsoralen (8\u2010MOPS) with subsequent UVA irradiation (bath\u2010PUVA) or oral administration of 8\u2010MOPS with UVA is used to treat mycosis fungoides. We retrospectively analyzed 62 patients with mycosis fungoides (8\u00a0stage IA, 30\u00a0stage IB, 5\u00a0stage IIB, 18\u00a0stage IIIA, and 1\u00a0stage IVA2) treated with bath\u2010PUVA at the Dermatology Clinic of Nagoya City University Hospital from November 2004 to December 2013. A complete response was achieved in 37 (59.7%) patients, a partial response was achieved in 16 (25.8%), and stable disease was achieved in 6 (9.7%). Progressive disease was observed in 3 (4.8%) patients. Almost all patients in stage IA\/IB achieved a complete response. Of the 5 stage IIB patients, 2 achieved a partial response, 1 achieved stable disease, and 2 had progressive disease. The serum concentrations of soluble interleukin\u20102 receptor and lactate dehydrogenase decreased significantly following treatment with bath\u2010PUVA (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). We examined the risk factors of patients whose stage progressed despite PUVA treatment. A multivariate Cox regression analysis of risk factors associated with stage progression yielded a hazard ratio of 28.5 for stage IIb. Treatment with bath\u2010PUVA is highly effective in the early stages of mycosis fungoides, and partially effective in advanced stages.<\/jats:p>","DOI":"10.1111\/1346-8138.16077","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T14:38:01Z","timestamp":1627310281000},"page":"239-245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy of bath\u2010psoralen and ultraviolet A therapy for mycosis fungoides \u2013 retrospective analysis of 62 cases"],"prefix":"10.1111","volume":"49","author":[{"given":"Yoichi","family":"Shintani","sequence":"first","affiliation":[{"name":"Department of Geriatric and Environmental Dermatology Nagoya City University Graduate School of Medical Sciences  Nagoya 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