{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:24:03Z","timestamp":1791645843587,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hemoporfin\u2010mediated photodynamic therapy (HMME\u2010PDT) is a vascular\u2010targeted treatment for port\u2010wine stains (PWS). However, the efficacy of this has varied and is difficult to predict. The objective of this study was to evaluate the efficacy of influential factors associated with HMME\u2010PDT and provide a suitable method for predicting the efficacy. Patients with facial PWS who underwent HMME\u2010PDT were retrospective analyzed. A total of 212 patients (93 males) with mean age of 13.01\u00a0\u00b1\u00a012.67\u00a0years (range, 1\u201351) years were included. There were 143 cases with red, 56 cases with purple, and 13 cases with hypertrophic\u2010type PWS. The number of HMME\u2010PDT sessions ranged 1\u20136. The excellent response rate after 1\u20134 PDT sessions was 9.4%, 17.6%, 32.7%, and 42.9%, respectively. The number of PDT treatments is associated with efficacy, and patients who underwent treatment with more than three sessions had response better than those who underwent treatment with less than three sessions (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003). Response to HMME\u2010PDT in patients of different ages, previous treatment history, lip involvement, and vessels morphology showed significant differences after two treatment sessions (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001, 0.03, 0.014, and 0.001, respectively), while patients of different sex, subtype, lesion size, location (medial, lateral, or mixed), or non\u2010vascular morphology showed no significant differences. Logistic regression analysis confirmed that the patients with lip hypertrophy (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002), history of more than five times prior treatment (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003), fewer PDT sessions (&lt;3) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.000002), linear vessels (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.007), and reticular vessels (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0003) showed association with poor response of HMME\u2010PDT. In conclusion, HMME\u2010PDT is an effective treatment for PWS. Patients who had underwent treatment for more than five times prior, lip hypertrophy, and linear vessels or reticular vessels under dermoscope showed association with poor efficacy.<\/jats:p>","DOI":"10.1111\/1346-8138.16094","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T07:19:16Z","timestamp":1628234356000},"page":"1700-1708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Efficacy of influential factors in hemoporfin\u2010mediated photodynamic therapy for facial port\u2010wine stains"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3429-9584","authenticated-orcid":false,"given":"Yuanbo","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Nanjing Medical University Affiliated Wuxi People\u2019s Hospital Wuxi 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