{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:42:07Z","timestamp":1788381727509,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Women with abnormal uterine bleeding (AUB) have been reported to develop chronic spontaneous urticaria (CSU). Nevertheless, whether or not AUB women have an increased risk of CSU has not been examined in large\u2010scale epidemiologic studies. This study aimed to investigate the risk of CSU among reproductive\u2010aged women with AUB. A total of 79\u00a0595 patients and 79\u00a0107 propensity\u2010score matched controls were recruited from Taiwan\u2019s National Health Insurance Research Database to conduct a nationwide cohort study. The Cox proportional\u2010hazard regression model was applied to examine the adjusted hazard ratios (aHR) and 95% confidence intervals (CI) for CSU in relation to AUB. We found that women with AUB had a higher risk for CSU (aHR\u00a0=\u00a01.83; 95% CI, 1.76\u20131.90) than women without AUB. Subgroup analyses revealed that AUB with an abnormal bleeding frequency (aHR\u00a0=\u00a01.70; 95% CI, 1.60\u20131.79), irregular bleeding (aHR\u00a0=\u00a01.80; 95% CI, 1.71\u20131.89), and intermenstrual bleeding (aHR\u00a0=\u00a01.65; 95% CI, 1.49\u20131.83) were associated with an increased risk of CSU compared with those without abnormalities. The Kaplan\u2013Meier analysis revealed that the cumulative incidence of developing CSU was consistently higher in the AUB cohort than in the non\u2010AUB cohort during the entire follow\u2010up period (log\u2010rank test, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). In conclusion, reproductive\u2010aged women with AUB were found to have a higher risk of developing CSU. This study emphasizes the importance of enquiring CSU patients about menstrual problems in clinical practice. Further consultation with obstetrician\u2010gynecologists may be beneficial.<\/jats:p>","DOI":"10.1111\/1346-8138.16109","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T06:32:20Z","timestamp":1630391540000},"page":"1754-1762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Risk of chronic spontaneous urticaria in reproductive\u2010aged women with abnormal uterine bleeding: A population\u2010based cohort study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5761-8114","authenticated-orcid":false,"given":"Tai\u2010Li","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Medical Education Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien 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