{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:24:06Z","timestamp":1792506246296,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Glycopyrronium tosylate cloth, an anticholinergic drug, has been approved for the topical treatment of primary axillary hyperhidrosis in the USA, but its effects in Japanese patients have not been previously investigated. This 4\u2010week, randomized, double\u2010blind, vehicle\u2010controlled, multicenter study was conducted to evaluate the efficacy and safety of glycopyrronium tosylate cloth for primary axillary hyperhidrosis patients in Japan. Eligible patients, who were \u22659\u00a0years of age and had primary axillary hyperhidrosis \u22656\u00a0months, with gravimetrically\u2010measured sweat production \u226550\u00a0mg\/5\u00a0min, and Hyperhidrosis Disease Severity Scale \u22653 (moderate) were randomized 1:1:1 to once daily topical glycopyrronium tosylate 3.75%, 2.5%, or vehicle. Overall, 497 patients (163 in the glycopyrronium tosylate 3.75% group, 168 in the glycopyrronium tosylate 2.5% group, and 166 in the vehicle group, hereinafter in this order) were randomized. Statistically higher proportions of patients in the glycopyrronium tosylate groups achieved \u22652\u2010point improvement in Hyperhidrosis Disease Severity Scale and \u226550% reduction in sweat production from baseline versus vehicle at week 4 (51.6%, 41.1%, and 16.4%, respectively; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001 in both cases). Higher responder rates in the glycopyrronium tosylate groups compared with the vehicle group occurred as early as week 1. The most common treatment\u2010emergent adverse events in patients treated with glycopyrronium tosylate were photophobia, mydriasis, thirst, and dysuria. Most treatment\u2010emergent adverse events were mild as determined by the investigators. The incidence of treatment\u2010emergent adverse events leading to treatment modification was low in the three groups. The 4\u2010week use of topical glycopyrronium tosylate improved the patient\u2010reported outcome measure Hyperhidrosis Disease Severity Scale and objectively\u2010evaluated sweat production with a favorable benefit\/risk profile.<\/jats:p>","DOI":"10.1111\/1346-8138.16188","type":"journal-article","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T05:10:16Z","timestamp":1634015416000},"page":"86-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Topical glycopyrronium tosylate in Japanese patients with primary axillary hyperhidrosis: A randomized, double\u2010blind, vehicle\u2010controlled study"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5773-9485","authenticated-orcid":false,"given":"Hiroo","family":"Yokozeki","sequence":"first","affiliation":[{"name":"Department of Dermatology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Ikebukuro Nishiguchi Fukurou Dermatology Clinic  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Wanatabe","sequence":"additional","affiliation":[{"name":"Clinical Development Department Maruho Co., Ltd.  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Clinical Development Department Maruho Co., Ltd.  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Fujii","sequence":"additional","affiliation":[{"name":"Clinical Development Department Maruho Co., Ltd.  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