{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:54:49Z","timestamp":1791078889504,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To establish real\u2010world evidence about the safety and efficacy of bexarotene for Japanese patients with cutaneous T\u2010cell lymphoma, we conducted a nationwide cohort study using data from post\u2010marketing surveillance for bexarotene treatment. In total, 294 patients with cutaneous T\u2010cell lymphoma were identified between June 2016 and June 2018. Of these, 267 patients were included as the safety analysis set. Of the 267 patients, 175 were included in the efficacy analysis set. Of these, 139 patients had mycosis fungoides, including 46 with early stage disease and 93 with advanced stage disease. Among the 139 patients with mycosis fungoides, the objective response rate was 46.8%. A significant difference in objective response rate was detected between patients who started with bexarotene at 300\u00a0mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    (61.6%) and patients who started with bexarotene at less than 300\u00a0mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    (22.6%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). Of the 139 patients with mycosis fungoides, 92 were treated with a combination of bexarotene plus photo(chemo)therapy. A significant difference in objective response rate was seen between bexarotene with a combination of photo(chemo)therapy (57.6%) and bexarotene without a combination of photo(chemo)therapy (25.5%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). Starting bexarotene at 300\u00a0mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    and combination with photo(chemo)therapy were detected as independent factors influencing response. Common treatment\u2010related adverse events included hypothyroidism (85.8%), hypertriglyceridemia (68.5%), hypercholesterolemia (43.8%), and neutropenia (21.3%). Hypertriglyceridemia, hypercholesterolemia, and neutropenia occurred more frequently in patients who started with bexarotene at 300\u00a0mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    than patients who started with bexarotene at less than 300\u00a0mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    (hypertriglyceridemia, 76.4% vs. 57.0%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.001; hypercholesterolemia, 49.0% vs. 36.4%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.045; neutropenia, 28.0% vs. 12.1%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.002; respectively). The present study indicates that starting bexarotene at 300\u00a0mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    and combination of photo(chemo)therapy offer a promising efficacy for the treatment of patients with mycosis fungoides. Efficacy of low\u2010dose bexarotene plus photo(chemo)therapy should be evaluated in future.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.16201","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T02:35:52Z","timestamp":1634783752000},"page":"253-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Safety and efficacy of bexarotene for Japanese patients with cutaneous T\u2010cell lymphoma: Real\u2010world experience from post\u2010marketing surveillance"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4192-5707","authenticated-orcid":false,"given":"Toshihisa","family":"Hamada","sequence":"first","affiliation":[{"name":"Department of Dermatology Takamatsu Red Cross Hospital Takamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8372-3754","authenticated-orcid":false,"given":"Akimichi","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Geriatric and Environmental Dermatology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4212-8278","authenticated-orcid":false,"given":"Hiraku","family":"Suga","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikari","family":"Boki","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6809-5833","authenticated-orcid":false,"given":"Taku","family":"Fujimura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2201-6129","authenticated-orcid":false,"given":"Yoji","family":"Hirai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dentistry and Pharmaceutical Sciences Okayama University Graduate School of Medicine Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0369-869X","authenticated-orcid":false,"given":"Takatoshi","family":"Shimauchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiharu","family":"Tateishi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Kiyohara","sequence":"additional","affiliation":[{"name":"Department of Dermatology Course of Integrated Medicine Graduate School of Medicine Osaka University Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikko","family":"Muto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6406-962X","authenticated-orcid":false,"given":"Hideki","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kochi Medical School Kochi University Nankoku 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