{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:20:54Z","timestamp":1747182054107,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We analyzed the serum zinc levels of 37 patients with 40 phlegmon lesions. The mean serum zinc level was 52.1\u00a0\u00b1\u00a016.4\u00a0\u03bcg\/dL. The serum zinc level was negatively correlated with the C\u2010reactive protein (CRP) level (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.66) and white blood cell (WBC) count (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.56). It was also positively correlated with the serum levels of albumin, hemoglobin, and hematocrit (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.57, 0.50, and 0.50, respectively). Patients with serum zinc levels of &lt;60\u00a0\u03bcg\/dL had higher CRP levels and WBC counts (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.005 and <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05, respectively) and lower albumin, hemoglobin, and hematocrit levels (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01, and <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01, respectively), and were more likely to be hospitalized (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) than those with serum zinc levels of \u226560\u00a0\u03bcg\/dL. Patients with low serum zinc levels were given zinc tablets. Three of the seven patients who developed recurrent phlegmons did not develop any further lesions after taking zinc tablets for &gt;10\u00a0months. Of the remaining patients, one only developed a minimal lesion, and another two experienced recurrence twice but did not have any further lesions for 10 and 15\u00a0months, respectively. These findings indicate that in patients with phlegmons the serum zinc level is a suitable marker of the severity of infection, and zinc supplementation reduces the risk of further recurrence in patients whose lesions relapse.<\/jats:p>","DOI":"10.1111\/1346-8138.16209","type":"journal-article","created":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T04:34:46Z","timestamp":1634963686000},"page":"184-189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Serum zinc levels in patients with phlegmons as a marker of the severity of infection and the potential of zinc supplementation to reduce the risk of recurrence"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9945-7064","authenticated-orcid":false,"given":"Shigeruko","family":"Iijima","sequence":"first","affiliation":[{"name":"Department of Dermatology Ryugasaki Saiseikai Hospital  Ryugasaki Japan"},{"name":"Division of Dermatology Hanamizuki Clinic  Ushiku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Takayama","sequence":"additional","affiliation":[{"name":"Division of Gynecology Hanamizuki Clinic  Ushiku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,22]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"537","article-title":"Zinc metabolism in patients with the syndrome of iron deficiency anemia, hepatosplenomegaly, dwarfism, and hypogonadism","volume":"61","author":"Prasad AS","year":"1963","journal-title":"J Lab Clin Med"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9060624"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/npmj.npmj_79_18"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.1.1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2015.12.006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jctube.2017.01.001"},{"key":"e_1_2_6_8_1","first-page":"260","article-title":"Serum zinc deficiency increases susceptibility to infection in older patients who have long\u2010term hospitalization","volume":"19","author":"Ukita T","year":"2008","journal-title":"Biomed Res Trace Elements"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.3.837"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/709152"},{"key":"e_1_2_6_11_1","first-page":"52","article-title":"Clinical significance of the serum zinc level in patients with phlenmone","volume":"39","author":"Tsunoda T","year":"2014","journal-title":"Yamagata Saiseikan Med J"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21082941"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.16209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.16209","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.16209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T06:59:40Z","timestamp":1722581980000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.16209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,22]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/1346-8138.16209"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.16209","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"type":"print","value":"0385-2407"},{"type":"electronic","value":"1346-8138"}],"subject":[],"published":{"date-parts":[[2021,10,22]]},"assertion":[{"value":"2021-06-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}