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This study aimed to construct and evaluate a nomogram model containing three clinical parameters to predict the recurrence risk of CA after 5\u2010aminolevulinic acid photodynamic therapy (ALA\u2010PDT). A predictive model was established based on a training cohort of 346 CA patients treated with ALA\u2010PDT between January 2013 and July 2018. A validation cohort of 123 CA patients was recruited from August 2018 to December 2019. The least absolute shrinkage and selection operator (LASSO) regression model was used to optimize the clinical feature selection. A nomogram predicting the recurrence of CA after ALA\u2010PDT was constructed based on the predictors identified by LASSO regression. C\u2010index and area under the curve (AUC) values were used to evaluate the discrimination. Calibration was evaluated with a calibration curve. The net benefit was performed via decision curve analysis (DCA).<\/jats:p><jats:p>In the training cohort, 55 (15.89%) patients experienced recurrences after ALA\u2010PDT. Predictors selected by LASSO regression were concomitant human immunodeficiency virus (HIV) infection [Hazard ratio (HR)\u00a0=\u00a04.4; 95% confidence interval (CI), 2.5\u20137.9; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001], skin and mucosa as affected area (HR\u00a0=\u00a01.7; 95% CI, 0.9\u20133.1; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.109), and more than one time of CO<jats:sub>2<\/jats:sub> laser therapy (HR\u00a0=\u00a06.3; 95% CI, 2.8\u201313.9; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). The nomogram showed a good performance in predicting recurrence as the C\u2010indexes were 0.843 (95% CI, 0.799\u20130.887) in the training cohort, and 0.831 (95% CI, 0.727\u20130.934) in the validation cohort. The AUCs of the nomogram were 0.85 in training and 0.8 in validation. DCA confirmed the nomogram was clinically useful when the intervention was determined at the non\u2010adherence possibility threshold of 5%. This nomogram can provide individualized prediction for the recurrence risk of CA in patients treated by ALA\u2010PDT.<\/jats:p>","DOI":"10.1111\/1346-8138.16218","type":"journal-article","created":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T04:46:22Z","timestamp":1636173982000},"page":"272-281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A novel nomogram based on a retrospective study of 346 patients to predict the recurrence risk of condyloma acuminatum after 5\u2010aminolevulinic acid photodynamic therapy"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8284-8547","authenticated-orcid":false,"given":"Shu","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Dermatology Nantong Third People\u2019s Hospital Affiliated to Nantong University  Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nantong Third People\u2019s Hospital Affiliated to Nantong University  Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhinan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nantong Third People\u2019s Hospital Affiliated to Nantong University  Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqun","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nantong Third People\u2019s Hospital Affiliated to Nantong University  Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingrong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical University  Nanjing 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