{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:21:00Z","timestamp":1747182060020,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T00:00:00Z","timestamp":1637452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Project\u2010ID 422744262 \u2013 TRR 289"],"award-info":[{"award-number":["Project\u2010ID 422744262 \u2013 TRR 289"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients suffering from chronic inflammatory diseases such as psoriasis are prone to develop depressive symptoms. However, within the time constraints of dermatological clinics, depressive symptoms in psoriasis patients are often overlooked and thus underdiagnosed. The Two Questions Test may serve as a quick screening tool for an initial assessment of depressive burden in these patients. We evaluated its usefulness in the clinical context analyzing the records of patients starting systemic treatment for psoriasis with a selective interleukin (IL)23\u2010 or IL17A\u2010inhibitor. In a total sample of <jats:italic>N<\/jats:italic>\u00a0=\u00a0139 patients, baseline Two Questions Test scores were analyzed together with measures of psoriatic and psychiatric symptoms. In addition, the development of the Two Questions Test scores over the course of the first 28\u00a0weeks of treatment was assessed. No association was found between the Two Questions Test scores and skin symptoms measured by the Psoriasis Area and Severity Index and the visibility of skin lesions. However, skin related quality of life analyzed with the Dermatology Life Quality Index was associated with the Two Questions Test scores. In addition, the longitudinal analysis revealed improvement in Two Questions Test outcomes over the course of patients\u2019 treatment. These results indicate the Two Questions Test's usefulness both as an initial screening tool of depressive symptoms, as well as in its use as a sensitive tool for the repeated assessment of depressive symptoms in psoriasis patients.<\/jats:p>","DOI":"10.1111\/1346-8138.16241","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T07:36:03Z","timestamp":1637566563000},"page":"341-348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A brief screening tool for depression in psoriasis patients: The Two Questions Test in clinical practice"],"prefix":"10.1111","volume":"49","author":[{"given":"Stefanie","family":"H\u00f6lsken","sequence":"first","affiliation":[{"name":"Institute of Medical Psychology and Behavioral Immunobiology University Hospital Essen University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik","family":"Krefting","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Hospital Essen University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Hospital Essen University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Benson","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology and Behavioral Immunobiology University Hospital Essen University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Schedlowski","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology and Behavioral Immunobiology University Hospital Essen University of Duisburg\u2010Essen  Essen Germany"},{"name":"Department of Clinical Neuroscience Osher Center for Integrative Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3684-3523","authenticated-orcid":false,"given":"Wiebke","family":"Sondermann","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Hospital Essen University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.339"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1252022"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804595"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.4029"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3114"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.186"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16436"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0279-8"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16250"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000102029"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.25251\/skin.3.2.39"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2019.03.002"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000492784"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.1997.00076.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-008913"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/ddg.12643","article-title":"Early detection of comorbidity in psoriasis: recommendations of the National Conference on Healthcare in Psoriasis","volume":"13","author":"Radtke MA","year":"2015","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1111\/ddg.14203","article-title":"Two questions may be enough \u2010 screening for depression in patients with psoriasis: a multicenter study","volume":"18","author":"Gerdes S","year":"2020","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13428-020-01398-0"},{"key":"e_1_2_7_22_1","unstructured":"The jamovi project: Jamovi (Version 1.6).2021. 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