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We aimed to characterize heterogenous manifestations in patients with full\u2010blown BD fulfilling the major diagnostic criteria in use. We retrospectively analyzed 338 patients diagnosed with complete BD based on Japanese diagnostic criteria, which fulfill both International Study Group (ISG) criteria and the International Criteria for BD (ICBD). Unbiased clustering analysis was performed to elucidate the heterogeneous spectrum, followed by subgroup analysis of identified clusters. Results of unbiased clustering analysis identify dominant skin lesion type as an important factor that determines clustering among the heterogenous BD patients. Regression analysis reveals that presence of predominantly\u00a0papulopustular lesions has protective effect for vascular involvement compared to other skin phenotypes. In conclusion, unbiased clustering analysis highlights that dermatologic manifestation can be a factor to understand the heterogeneity of BD and determining the dominant type of skin lesions may help clinicians predict major vascular involvement.<\/jats:p>","DOI":"10.1111\/1346-8138.16250","type":"journal-article","created":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T04:29:51Z","timestamp":1638592191000},"page":"349-358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Skin manifestation as an explaining factor of heterogeneity in Beh\u00e7et's disease: A focused analysis in full\u2010blown conditions"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2121-3553","authenticated-orcid":false,"given":"Kyung Bae","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9995-7643","authenticated-orcid":false,"given":"Sooyie","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6476-4259","authenticated-orcid":false,"given":"Dongsik","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, International St. Mary\u2019s Hospital Catholic Kwandong University  Incheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0194-9854","authenticated-orcid":false,"given":"Do\u2010Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,3]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et's disease. 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