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We report a case of NS confirmed by whole exome sequencing of DNA using peripheral blood, and Sanger sequencing found two new mutations associated with her clinical presentation located at <jats:italic>SPINK5<\/jats:italic> gene c.1220+5G&gt;A from her father and c.1870delA from her mother. The patient was treated with dupilumab (600\u00a0mg at week 0, then 300\u00a0mg every 2\u00a0weeks, s.c.). The clinical manifestation and dermoscopic images of the patient\u2019s hair showed remarkable improvement after dupilumab treatment with no adverse effects. We also reviewed previous reports to learn more about the therapeutic effect and adverse reactions of NS treated with dupilumab.<\/jats:p>","DOI":"10.1111\/1346-8138.16253","type":"journal-article","created":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T04:28:12Z","timestamp":1638592092000},"page":"165-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Successful treatment of Netherton syndrome with dupilumab: A case report and review of the literature"],"prefix":"10.1111","volume":"49","author":[{"given":"Jianbo","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology Henan Provincial People\u2019s Hospital Zhengzhou University People\u2019s Hospital Henan University People\u2019s Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henan 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