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Reportedly, nucleoside diphosphate\u2010linked moiety X\u2010type motif 15 (<jats:italic>NUDT15<\/jats:italic>) polymorphisms have been strongly associated with thiopurine\u2010induced leukopenia. To investigate hematological AE of low\u2010dose AZA based on <jats:italic>NUDT15<\/jats:italic> genotypes among patients with PV, a prospective cohort study was conducted in patients with PV, followed\u2010up for the first 8\u00a0weeks after AZA administration. All patients were divided into wild homozygous and heterozygous <jats:italic>NUDT15<\/jats:italic> groups. Both groups initiated AZA at low dose (50\u00a0mg\/day) and continued with different dose\u2010escalating approaches. Bone marrow suppression was considered the principal outcome. Overall, 62 patients with PV were enrolled (48 in the wild homozygous <jats:italic>NUDT15<\/jats:italic> group vs. 14 in the heterozygous <jats:italic>NUDT15<\/jats:italic> group). Except for median maintenance doses of AZA, no statistically significant differences were observed between the two groups in terms of age, sex, white blood cells, neutrophil count, platelet count, hemoglobin level, median final doses of corticosteroids (mg prednisone equivalent), pemphigus disease area index, and anti\u2010desmoglein 1\/3 autoantibodies. In both groups, patients presented similar hematological AE and treatment responses after administration of different low\u2010dose AZA treatment strategies. Low\u2010dose AZA based on <jats:italic>NUDT15<\/jats:italic> genotypes can reduce the risk of early hematological AE among patients with PV.<\/jats:p>","DOI":"10.1111\/1346-8138.16265","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T04:34:36Z","timestamp":1638765276000},"page":"402-410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of <i>NUDT15<\/i> polymorphisms on early hematological safety of low\u2010dose azathioprine in Chinese patients with pemphigus vulgaris: A prospective cohort study"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7060-254X","authenticated-orcid":false,"given":"Xingli","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Dermatology Rare Diseases Center West China Hospital Sichuan University  Chengdu 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