{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:21:02Z","timestamp":1747182062828,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:00:00Z","timestamp":1640044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872533","81872534","81903223","81974477"],"award-info":[{"award-number":["81872533","81872534","81903223","81974477"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is a chronic inflammatory skin disease with multiple genetic backgrounds, whose etiology and pathogenesis are still unclear. Complex T\u2010cell immune imbalance has been demonstrated to play an important role in pathogenesis of psoriasis. This study reported that microRNA\u2010126 (miR\u2010126) expression was decreased in CD4<jats:sup>+<\/jats:sup> T cells of both psoriasis patients and psoriasis\u2010like mouse models and its expression was negatively correlated with the Psoriasis Area and Severity Index (PASI) score of psoriasis patients. Conditional <jats:italic>Mir126<\/jats:italic> knockout in mouse CD4<jats:sup>+<\/jats:sup> T cells can obviously aggravate the psoriasis\u2010like dermatitis and promote T\u2010helper (Th)1 and Th17 cells\u2019 infiltration in spleen of imiquimod (IMQ)\u2010induced psoriasis\u2010like mouse model. In addition, the mRNA expression of <jats:italic>Il17a<\/jats:italic> and <jats:italic>Il17f<\/jats:italic> were significantly increased in mouse na\u00efve CD4<jats:sup>+<\/jats:sup> T cells with <jats:italic>Mir126<\/jats:italic> knockout after stimulating with CD3 and CD28. Compared with na\u00efve CD4<jats:sup>+<\/jats:sup> T cells, the expression of <jats:italic>Mir126<\/jats:italic> was decreased in Th17 cells, and <jats:italic>Mir126<\/jats:italic> knockout notably promoted the differentiation of na\u00efve CD4<jats:sup>+<\/jats:sup> T cells to Th17 cells as well as the mRNA expression of <jats:italic>Il17a<\/jats:italic>, <jats:italic>Il17f<\/jats:italic>, <jats:italic>Rorc<\/jats:italic>, and <jats:italic>Il23R<\/jats:italic>. Our results revealed that decreased miR\u2010126 in psoriatic CD4<jats:sup>+<\/jats:sup> T cells might accelerate the formation of skin lesions through promoting the differentiation of Th17 cells, thus suggesting a potential intervention target for psoriasis.<\/jats:p>","DOI":"10.1111\/1346-8138.16272","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T08:54:26Z","timestamp":1640076866000},"page":"432-440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Decreased microRNA\u2010126 expression in psoriatic CD4<sup>+<\/sup> T cells promotes T\u2010helper 17 cell differentiation and the formation of dermatitis in imiquimod\u2010induced psoriasis\u2010like mice"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9923-949X","authenticated-orcid":false,"given":"Ruifang","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Dermatology 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