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We reviewed the various surgical therapies and innovative approaches for vitiligo regenerative treatment reported in the literature. Surgical therapies can be subdivided into tissue grafting methods and cellular grafting methods. Tissue grafting methods mainly include mini punch grafts, suction blister roof grafts, and hair follicle grafts. Cellular grafting methods include cultured and non\u2010cultured treatments. The efficacy needs to be improved largely due to the poor proliferation and quality of the autologous melanocytes. Rho\u2010associated protein kinase inhibitor enhances primary melanocyte culture proliferation from vitiligo patients to prevent apoptosis. Innovative approaches using stem cell methods could prove invaluable in developing a novel cell therapy for patients suffering from vitiligo. We succeeded in inducing melanin pigmentation in mice skin <jats:italic>in vivo<\/jats:italic> using our human induced pluripotent stem cell\u2010derived melanocytes. In addition, we reviewed melanocytorrhagy, detachment and transepidermal loss of melanocytes, and melanocyte\u2010related adhesion molecules. These adhesion molecules include epithelial cadherin, discoidin domain receptor tyrosine kinase 1, glycoprotein non\u2010metastatic melanoma protein B, macrophage migration inhibiting factor, 17\u03b2\u2010hydroxysteroid dehydrogenase 1, and E26 transformation\u2010specific 1.<\/jats:p>","DOI":"10.1111\/1346-8138.16316","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T07:08:13Z","timestamp":1645168093000},"page":"391-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Surgical procedures and innovative approaches for vitiligo regenerative treatment and melanocytorrhagy"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6741-939X","authenticated-orcid":false,"given":"Tamihiro","family":"Kawakami","sequence":"first","affiliation":[{"name":"Division of Dermatology, Tohoku Medical and Pharmaceutical University  Sendai 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