{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:12:59Z","timestamp":1789773179026,"version":"4.0.1"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T00:00:00Z","timestamp":1645920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dupilumab, a monoclonal antibody that specifically inhibits signal transductions by interleukin (IL)\u20104 and IL\u201013, has been used to treat T\u2010helper (Th)2\u2010type allergic disorders, including atopic dermatitis and asthma. We report a 21\u2010year\u2010old female patient with atopic dermatitis who developed systemic lupus erythematosus (SLE) unexpectedly after dupilumab treatment. Her skin lesions partially improved after dupilumab treatment; however, a part of her skin lesions on the face, nape, and upper extremities were refractory even after a 15\u2010month period of dupilumab treatment. These dupilumab\u2010refractory skin lesions were histopathologically diagnosed as cutaneous lupus erythematosus, moreover, subsequent phenomenons, diffuse alopecia, joint pain, lymphopaenia, hypocomplementemia, and positivities for anti\u2010nuclear, anti\u2010double\u2010stranded DNA, anti\u2010U1 ribonucleoprotein, anti\u2010Smith, and anti\u2010Sj\u00f6gren's syndrome\u2010related antigen A antibodies made a diagnosis of SLE. Our retrospective investigations on her serum samples indicted that these abnormalities of laboratory examinations had not appeared at the initiation of dupilumab treatment. Our case at least indicated that dupilumab was not effective in treating SLE. Moreover, inhibition of Th2\u2010type immune responses by dupilumab may accelerate the pathogenesis of Th1\u2010related inflammatory disorders, including SLE, as observed in our case. Our case also presented another possibility that dupilumab has no effect on the progression of underlying SLE. Because a significant relationship exists between atopic dermatitis\/asthma and the risk of SLE, the utility of dupilumab should be carefully considered for each case.<\/jats:p>","DOI":"10.1111\/1346-8138.16322","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T06:25:30Z","timestamp":1646029530000},"page":"556-559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Development of systemic lupus erythematosus after dupilumab treatment in a case of atopic dermatitis"],"prefix":"10.1111","volume":"49","author":[{"given":"Mari","family":"Okune","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine University of Tsukuba  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5398-0773","authenticated-orcid":false,"given":"Naoko","family":"Okiyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine University of Tsukuba  Ibaraki Japan"},{"name":"Department of Dermatology, Graduate School of Medical and Dental Science Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Fukuzono","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine University of Tsukuba  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhito","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine University of Tsukuba  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine University of Tsukuba  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18730"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar290"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-020-00458-6"},{"key":"e_1_2_6_5_1","first-page":"500","article-title":"Atopic eczema complicated by systemic lupus erythematosus","volume":"15","author":"Higashi N","year":"2005","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg026"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2018.08.027"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16383"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1624683"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2021.04.035"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2017.53"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.16322","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.16322","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.16322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T15:11:59Z","timestamp":1692976319000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.16322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,27]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/1346-8138.16322"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.16322","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,27]]},"assertion":[{"value":"2021-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}