{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T02:51:24Z","timestamp":1777344684163,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is a chronic immune\u2010mediated inflammatory skin disease characterized by hyperproliferation of epidermal keratinocytes. Biologics have been available for the treatment of patients with refractory psoriasis since 2010 in Japan, and as of December 2021, 10 biologics were available. The Biologics Review Committee of the Japanese Dermatological Association for Psoriasis recommends blood examination tests for antinuclear antibodies (ANA), Krebs von den Lugen (KL)\u20106, hepatitis B surface antigen (HBsAg), hepatitis B surface antibodies (HBsAb), hepatitis B core antibodies (HBcAb), hepatitis C virus (HCV) antibodies, HIV antibodies, human T\u2010cell leukemia virus (HTLV)\u20101 antibodies, \u03b2\u2010D\u2010glucan, and the T\u2010cell spot (T\u2010SPOT) test before initiation of biologics at screening. In this study, we evaluated the use of biologics for 127 psoriasis patients and the blood examination screening data before initiation of biologics in the real\u2010world setting. Tumor necrosis factor inhibitors, interleukin (IL)\u201017 inhibitors and IL\u201023 inhibitors were initiated for 54 (42.5%), 36 (28.3%), and 37 (29.1%) patients, respectively. The numbers of patients positive for ANA, HBsAg, HBsAb, HBcAb, HCV antibody, HIV antibody, HTLV\u20101 antibody, and T\u2010SPOT were 27 (21.3%), 0 (0%), 22 (17.3%), 20 (15.7%), three (2.4%), zero (0%), one (0.8%), and 4 (3.1%), respectively. The numbers of patients whose KL\u20106 and \u03b2\u2010D\u2010glucan levels were higher than the reference values were seven (5.5%) and seven (5.5%), respectively. In the real\u2010world setting, it is sometimes unavoidable to use biologics for those patients with abnormal data although careful monitoring is necessary.<\/jats:p>","DOI":"10.1111\/1346-8138.16333","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T06:27:40Z","timestamp":1645597660000},"page":"534-538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Real\u2010world blood examination screening data before initiation of biologics for psoriasis patients"],"prefix":"10.1111","volume":"49","author":[{"given":"Saeko","family":"Ozaki","sequence":"first","affiliation":[{"name":"Department of Dermatology Nippon Medical School  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1508-9514","authenticated-orcid":false,"given":"Susumu","family":"Ichiyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology 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